▪ ABSTRACT
Introduction:
Visible scars can cause problems, whether aesthetic, psychological,
functional, or social, mainly of great extension and volume, such as
keloids. The discovery of new treatments for keloids is not easy, given the
presence of some methodological and ethical obstacles, and it is an area
that is little explored. Botulinum toxin has been presented as a therapeutic
alternative in national and international studies, requiring a compilation
and highlighting of the main studies that can support clinical practice.
Thus, the objective was to present a scoping review on the therapeutic use
of botulinum toxin for the treatment of keloid scars.
Method:
The review was
carried out using the PICO strategy and using the Preferred Reporting Items
for Systematic Reviews and Meta-Analyses extension for Scoping Reviews. It
was carried out in the PubMed/Medline, Virtual Health Library, and SciELO
databases, considering studies from 2016 to September 2021.
Results:
Overall, 34 articles related to the topic were found. After filtering and
selection, the review was constructed with the support of 5 articles. The
studies varied between cohorts, case reports, randomized clinical trials,
and case-control. It was possible to observe as main results of the
short-term action of botulinum toxin in reducing keloids, greater
effectiveness in reducing symptoms, and possibilities of clinical use for
different populations and clinical manifestations.
Conclusion:
The mechanism of action of botulinum toxin can facilitate the treatment of keloids
and
reduce symptoms, requiring more robust studies to define effective scar
management protocols.
Keywords: Keloid - Therapeutic Human experimentation - Botulinum toxins, type A - Reconstructive
surgical procedures - Evidence-based practice
Bibliographical Record
