Open Access
CC BY-NC-ND 4.0 · Sleep Sci 2022; 15(01): 75-81
DOI: 10.5935/1984-0063.20210034
ORIGINAL ARTICLE

Changes in pharyngeal anatomy and apnea/hypopnea index after a mandibular advancement device

Autor*innen

  • Juan-Manuel Cortes-Mejia

    1   Sleep Disorders Clinic, Universidad Autónoma Metropolitana, Sleep Disorder Clinic - Mexico City - Ciudad De Mexico - Mexico.
  • Ana Boquete-Castro

    2   Postgraduate in dentistry. Catholic University of San Antonio. Murcia, Spain.
  • Yoaly Arana-Lechuga

    1   Sleep Disorders Clinic, Universidad Autónoma Metropolitana, Sleep Disorder Clinic - Mexico City - Ciudad De Mexico - Mexico.
    3   Neurosciences and Sleep Disorders Center., Sleep Disorder Clinic - Ciudad De Mexico - México.
  • Guadalupe Jovanna Terán-Pérez

    3   Neurosciences and Sleep Disorders Center., Sleep Disorder Clinic - Ciudad De Mexico - México.
  • Katiuska Casarez-Cruz

    4   National Institute of Neurology and Neurosurgery, Imagen Center - Ciudad De Mexico - México.
  • Rosa Obdulia González-Robles

    5   Universidad Autónoma Metropolitana, Mathematics Department - Ciudad de Mexico - Ciudad De Mexico.
  • Javier Velázquez-Moctezuma

    1   Sleep Disorders Clinic, Universidad Autónoma Metropolitana, Sleep Disorder Clinic - Mexico City - Ciudad De Mexico - Mexico.
    3   Neurosciences and Sleep Disorders Center., Sleep Disorder Clinic - Ciudad De Mexico - México.

ABSTRACT

Objectives: This study aimed to evaluate the therapeutic effcacy of custom-made mandibular advancement devices (MAD) in the control of primary snoring and sleep apnea and to correlate with anatomical changes identified through imaging tests.

Methods: Patients (n = 17) diagnosed with sleep apnea or primary snoring were included in this study and subsequently treated with MADs. Changes were assessed using a polysomnographic study (PSG), the Epworth Sleepiness Scale (ESS), and an imaging study with computed tomography scanning (CT). Studies were performed before and after the use of MAD. Anteroposterior measurements were taken in the sagittal plane at the hard palate, glottis, and supraglottic levels along the hard palate axis. Afterward, measurements were taken in the axial plane at the same levels along the hard palate axis.

Results: From the six recorded measurements, the airway caliber increased by five. However, these changes were significant only in two measurements (sagittal hard palate and axial supraglottic). Snoring was controlled in 16 of the 17 subjects. From these sixteen, 12 subjects had a correct opening of the airway at the hard palate level. Moreover, daytime sleepiness decreased in all subjects.

Discussion: Present results suggest that sagittal hard palate and axial supraglottic opening after use of MAD are mainly responsible for eliminating snoring and improve sleep apnea.

FUNDING SOURCE

This work was primarily supported by Consejo Nacional de Ciencia y Tecnología, Conacyt 2013-1-201587.




Publikationsverlauf

Eingereicht: 03. November 2020

Angenommen: 31. Mai 2021

Artikel online veröffentlicht:
01. Dezember 2023

© 2022. Brazilian Sleep Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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  • REFERENCES

  • 1 Jordan AS, McSharry DG, Malhotra A. Adult obstructive sleep apnea. Lancet. 2014 Feb;383(9918):736-47.
  • 2 Lin J, Suurna M. Sleep apnea, and sleep-disordered breathing. Otolaryngol Clin North Am. 2018 Aug;51(4):827-33.
  • 3 Epstein LJ, Kristo D, Strollo Junior PJ, Friedman N, Malhotra A, et al. Clinical guideline for the evaluation, management, and long-term care of obstructive sleep apnea in adults. J Clin Sleep Med. 2009 Jun;5(3):263-76.
  • 4 Farrell PC, Richards G. Recognition and treatment of sleep-disordered breathing: an important component of chronic disease management. J Transl Med. 2017 May;15(1):114.
  • 5 Maspero C, Giannini L, Galbiati G, Rosso G, Farronato G. Obstructive sleep apnea syndrome: a literature review. Minerva Stomatol. 2015 Apr;64(2):97-109.
  • 6 American Academy for Sleep Medicine (AASM). International classification of sleep disorders. 3rd ed. Darien: AASM; 2014.
  • 7 Wojda M, Jurkowski P, Lewandowska A, Mierzwińska-Nastalska E, Kostrzewa- Janicka J. Mandibular advancement devices in patients with symptoms of obstructive sleep apnea: a review. Adv Exp Med Biol. 2019;1153:11-7.
  • 8 Rubio GS, Escalada EM, Canal JMM, Santos JT. Mandibular advancement devices in the treatment of obstructive sleep apnea. A necessary and effective option. Med Clin (Barc). 2018 Jul;151(1):34-38.
  • 9 Ramar K, Dort LC, Katz SG, Lettieri CJ, Harrod CG, Thomas SM, et al. Clinical practice guideline for the treatment of obstructive sleep apnea and snoring with oral appliance therapy: an update for 2015. J Clin Sleep Med. 2015 Jul;11(7):773-827.
  • 10 Marklund M, Braem MJA, Verbraecken J. Update on oral appliance therapy. Eur Respir Rev. 2019;28(153):190083.
  • 11 Kaur A, Chand P, Singh RD, Siddhartha R, Tripathi A, Tripathi S, et al. Computed tomographic evaluation of the effects of mandibular advancement devices on pharyngeal dimension changes in patients with obstructive sleep apnea. Int J Prosthodont. 2012 Sep/Oct;25(5):497-505.
  • 12 Giles TL, Lasserson TJ, Smith BJ, White J, Wright J, Cates CJ. Continuous positive airways pressure for obstructive sleep apnoea (Cochrane review). Cochrane Database Syst Rev. 2006 Jan;(1):CD001106.
  • 13 Wang TC, Tsou YA, Wu YF, Huang CC, Lin WW, Li YF, et al. Treatment success with titratable thermoplastic mandibular advancement devices for obstructive sleep apnea: a comparison of patient characteristics. Ear Nose Throat J. 2017 Mar;96(3):E25-E32.
  • 14 Gauthier L, Laberge L, Beaudry M, Laforte M, Rompré PH, Lavigne GJ. Efficacy of two mandibular advancement appliances in the management of snoring and mild- moderate sleep apnea: a cross-over randomized study. Sleep Med. 2009;10(3):329-36.
  • 15 Bloch KE, Iseli A, Zhang JN, Xie X, Kaplan V, Stoeckli PW, et al. A randomized, controlled crossover trial of two oral appliances for sleep apnea treatment. Am J Respir Crit Care Med. 2000 Jul;162(1):246-51.
  • 16 Pitarch RM, García MS, Cuesta JP, Algarra JM, Fernández E, Fons-Font A. Effectiveness of a mandibular advancement device in obstructive sleep apnea patients: a prospective clinical trial. Eur Arch Otorhinolaryngol. 2018 Jul;275(7):1903-11.
  • 17 Ono T, Lowe AA, Ferguson KA, Pae EK, Fleetham JA. The effect of the tongue- retaining device on awake genioglossus muscle activity in patients with obstructive sleep apnea. Am J Orthodont Dentofacial Orthoped. 1996 Jul;110(1):28-35.
  • 18 Prathibha BN, Jagger RG, Saunders M, Smith AP. Use of a mandibular advancement device in obstructive sleep apnea. J Oral Rehabil. 2003 May;30(5):507-9.
  • 19 Vigié du Cayla G, Collet JM, Attali V, Kerbrat JB, Benslama L, Goudot P. Long- term effectiveness and side effects of mandibular advancement devices on dental and skeletal parameters. J Stomatol Oral Maxillofac Surg. 2019 Feb;120(1):7-10.
  • 20 Schwartz M, Acosta L, Hung YL, Padilla M, Enciso R. Effects of CPAP and mandibular advancement device treatment in obstructive sleep apnea patients: a systematic review and meta-analysis. Sleep Breath. 2018 Sep;22(3):555-68.
  • 21 Collen J, Lettieri C, Kelly W, Roop S. Clinical and polysomnographic predictors of short-term continuous positive airway pressure compliance. Chest. 2009 Mar;135(3):704-9.
  • 22 Weaver TE, Grunstein RR. Adherence to continuous positive airway pressure therapy: the challenge to effective treatment. Proc Am Thorac Soc. 2008 Feb;5(2):173-8.
  • 23 Anandam A, Patil M, Akinnusi M, Jaoude P, El-Solh AA. Cardiovascular mortality in obstructive sleep apnea treated with continuous positive airway pressure or oral appliance: an observational study. Respirology. 2013 Nov;18(8):1184-90.
  • 24 Dieltjens M, Braem MJ, Vroegop AVMT, Wouters K, Verbraecken JA, De Backer WA, et al. Objectively measured vs self-reported compliance during oral appliance therapy for sleep-disordered breathing. Chest. 2013 Nov;144(5):1495-502.
  • 25 Sutherland K, Takaya H, Qian J, Petocz P, Ng AT, Cistulli PA. Oral appliance treatment response and polysomnographic phenotypes of obstructive sleep apnea. J Clin Sleep Med. 2015 Aug;11(8):861-8.
  • 26 Robin P. Glossoptosis due to atresia and hypotrophy of the mandible. JAMA Pediatr. 1934;48(3):541-7.
  • 27 Thorpy M, Chesson A, Derderian S, Kader G, Millman RP, Potolicchio S, et al. Practice parameters for the treatment of snoring and obstructive sleep apnea with oral appliances. Sleep. 1995;18(6):511-3.
  • 28 Ferguson K, Cartwright R, Rogers R, Schmidt-Nowara W. Oral appliances for snoring and obstructive sleep apnea: a review. Sleep. 2006;29(2):244-62.
  • 29 Kushida CA, Littner MR, Morgenthaler T, Alessi CA, Bailey D, Coleman Junior, et al. Practice parameters for the treatment of snoring and obstructive sleep apnea with oral appliances: an update for 2005. Sleep. 2006 Feb;29(2):240-3.
  • 30 Lim J, Lasserson TJ, Fleetham J, Wright J. Oral appliances for obstructive sleep apnea. Cochrane Database Syst Rev. 2006 Jan;2006(1):CD004435.
  • 31 Geoghegan F, Ahrensb A, McGrathc C, Hagg U. An evaluation of two different mandibular advancement devices on craniofacial characteristics and upper airway dimensions of Chinese adult obstructive sleep apnea patients. Angle Orthod. 2015 Nov;85(6):962-8.
  • 32 Chen H, Aarab G, Lobbezoo F, De Lange J, Van Der Stelt P, Darendeliler MA, et al. Differences in three-dimensional craniofacial anatomy between responders and non- responders to mandibular advancement splint treatment in obstructive sleep apnoea patients. Eur J Orthod. 2019 May;41(3):308-15.
  • 33 Mostafiz WR, Carley DW, Viana MGC, Ma S, Dalci O, Darendeliler MA, et al. Changes in sleep and airway variables in patients with obstructive sleep apnea after mandibular advancement splint treatment. Am J Orthod Dentofacial Orthop. 2019 Apr;155(4):498-508.
  • 34 Johnston CD, Gleadhill IC, Cinnamond MJ, Gabbey J, Burden DJ. Mandibular advancement appliances and obstructive sleep apnoea: a randomized clinical trial. Eur J Orthod. 2002 Jun;24(3):251-62.
  • 35 Johns MW. A new method for measuring daytime sleepiness: the sleepiness scale. Sleep. 1991 Dec;14(6):540-5.
  • 36 Johns M. Rethinking the assessment of sleepiness. Sleep Med Rev. 1998 Feb;2(1):3-15.
  • 37 Rosenthal LD, Dolan DC. The Epworth sleepiness scale in the identification of obstructive sleep apnea. J Nerv Ment Dis. 2008 May;196(5):429-31.
  • 38 Kaur A, Chand P, Singh RD, Siddhartha R, Tripathi A, Tripathi S, et al. Computed tomographic evaluations of the effects of mandibular advancement devices on pharyngeal dimension changes in patients with obstructive sleep apnea. Int J Prosthodont. 2012 Sep/Oct;25(5):497-505.
  • 39 Skalna M, Novak V, Buzga M, Skalny P, Hybaskova J, Stransky J, et al. Oral appliance effectiveness and patient satisfaction with obstructive sleep apnea treatment in adults. Med Sci Monit. 2019 Jan;25:516-24.
  • 40 Mouhanna-Fattal C, Papadopoulos M, Bouserhal J, Tauk A, Bassil-Nassif N, Athanasiou A. Evaluation of upper airway volume and craniofacial volumetric structures in obstructive sleep apnoea adults: a descriptive CBCT study. Int Orthod. 2019 Dec;17(4):678-86.
  • 41 Shete CS, Bhad WA. Three-dimensional upper airway changes with mandibular advancement device in patients with obstructive sleep apnea. Am J Orthod Dentofacial Orthop. 2017 May;151(5):941-8.