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CC BY-NC-ND 4.0 · Sleep Sci 2021; 14(01): 64-68
DOI: 10.5935/1984-0063.20190157
Short Communications

Impact of REM sleep deprivation and sleep recovery on circulatory neuroinflammatory markers

Konakanchi Suresh
1   Sri Devaraj Urs Medical College, Sri Devaraj Urs Academy of Higher Education and Research, Department of Physiology - Kolar - Karnataka - India.
,
Vinutha Shankar
1   Sri Devaraj Urs Medical College, Sri Devaraj Urs Academy of Higher Education and Research, Department of Physiology - Kolar - Karnataka - India.
,
Dayanand CD
2   Sri Devaraj Urs Medical College, Sri Devaraj Urs Academy of Higher Education and Research, Department of Biochemistry - Kolar - Karnataka - India.
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Objectives Sleep loss may contribute to neuroinflammation, which might increase neuroinflammatory markers such as neuron-specific enolase (NSE), creatine kinase-brain fraction (CK-BB), lactate dehydrogenase brain fraction (LDH-BB) in blood. Hence, we evaluated the effect of REM sleep deprivation and recovery on these markers.

Material and Methods Twenty-four adult male Sprague Dawley rats were grouped as control, environmental control, REM sleep deprivation, and 24 hour sleep recovery. The rats were sleep deprived for 72 hours and recovered for 24 hours. NSE, CK-BB, and LDH-BB levels in serum were measured using ELISA.

Results The serum NSE, CK-BB, and LDH-BB were significantly higher in 72 hour sleep deprived group compared to control (p<0.01). After 24 hours of sleep recovery, the levels of NSE, CK-BB, and LDH-BB were comparable to control (p>0.05).

Discussion REM sleep deprivation increased serum NSE, CK-BB, and LDH-BB, which might be due to neural damage. However, 24 hours of sleep recovery restored these markers.

REM Sleep Deprivation - Inflammation - Sleep Recovery - Neuron-Specific Enolase - Creatine Kinase-Brain Fraction - Lactate Dehydrogenase Brain Fraction

FUNDING SOURCE

We sincerely acknowledge the financial support (SDUAHER/Res. Project/152/2017-18) from Sri Devaraj Urs Academy of Higher Education and Research (SDUAHER), Kolar-563103, Karnataka, India.




Publication History

Received: 21 March 2020

Accepted: 22 July 2020

Article published online:
30 November 2023

© 2023. Brazilian Sleep Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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