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CC BY-NC-ND 4.0 · Sleep Sci 2018; 11(01): 49-53
DOI: 10.5935/1984-0063.20180011
ORIGINAL ARTICLE

Acute response to 7-day therapy with CPAP in patients with moderate to severe obstructive sleep apnea and cardiac arrhytmia

Authors

  • Jerónimo Campos

    1   Hospital Británico, Department of Respiratory Medicine - Capital - Buenos Aires - Argentina.

  • Glenda Ernst

    1   Hospital Británico, Department of Respiratory Medicine - Capital - Buenos Aires - Argentina.
    3   Hospital Británico, Argentine Group for Research into Sleep Apnea (GAIAS, for its Spanish acronym) - Capital - Buenos Aires - Argentina.

  • Magali Blanco

    1   Hospital Británico, Department of Respiratory Medicine - Capital - Buenos Aires - Argentina.

  • Alejandra Cassano

    4   Hospital Británico, Central Laboratory - Capital - Buenos Aires - Argentina.

  • Iván Tello-Santa-Cruz

    2   Hospital Británico, Department of Cardiology - Capital - Buenos Aires - Argentina.

  • Cesar Cáceres-Monié

    2   Hospital Británico, Department of Cardiology - Capital - Buenos Aires - Argentina.

  • Alexys Muyran

    4   Hospital Británico, Central Laboratory - Capital - Buenos Aires - Argentina.

  • Romina Cansonieri

    4   Hospital Británico, Central Laboratory - Capital - Buenos Aires - Argentina.

  • Alejandro Salvado

    1   Hospital Británico, Department of Respiratory Medicine - Capital - Buenos Aires - Argentina.

  • Eduardo Borsini

    1   Hospital Británico, Department of Respiratory Medicine - Capital - Buenos Aires - Argentina.
    3   Hospital Británico, Argentine Group for Research into Sleep Apnea (GAIAS, for its Spanish acronym) - Capital - Buenos Aires - Argentina.
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Introduction: Obstructive Sleep Apnea (OSA) has been associated with an elevated risk of cardiac arrhythmia. Continuous positive airway pressure (CPAP) is the selected treatment for moderate to severe OSA and could improve arrhythmias in the long term. However, the acute effect of CPAP has not been studied in detail.

Methods: We conducted a prospective study with 25 patients with moderate to severe OSA diagnosed by home respiratory polygraphy (RP) and arrhythmia and/or pauses in 24-hour Holter ECG. We analyzed inflammatory parameters and the rate of arrhythmias/pauses after 7 days of auto-adjusting CPAP.

Results: 92.5% of the patients were men with a mean age of 61.7±1.9 years. Body mass index (BMI) was 59.5±2.2 kg/m2, with a mean apnea hypopnea index (AHI) of 37.7±3.8 events/hour (ev/h), and a residual AHI (AHIr) of 5.3±0.53 ev/h. After short treatment with CPAP we observed a tendency to improvement in both the severity and number of ventricular extrasystoles (VE) (1595.0±850.3 vs. 926.4±434.5 respectively), pauses and the inflammatory parameters (CRP 3.9±3.1 vs. 1.7±1.2, glycemia 131.4±11.6 vs. 121.9±9.8, HOMA 24.4±3.1 vs.21.7±2.8, insulin 7.6±1.4 vs. 7.2±1.2 (p>0.5).

Conclusion: We didn't find significant changes in pauses, VE and inflammatory parameters with CPAP short therapy in CPAP naive patients recently diagnosed with OSA.

Arrhythmias, Cardiac - Blood Chemical Analysis - Sleep Apnea, Obstructive


Publication History

Received: 15 May 2017

Accepted: 26 January 2018

Article published online:
13 October 2023

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