An inflammatory link in atherosclerosis and obesity

A. Zirlik; E. Lutgens

doi:10.5482/HAMO-14-12-0079

Hämostaseologie, Table of Contents

Hamostaseologie 2015; 35(03): 272-278
DOI: 10.5482/HAMO-14-12-0079

Review

Schattauer GmbH

An inflammatory link in atherosclerosis and obesity

Co-stimulatory moleculesInflammation als Pathomechanismus in Atherosklerose und AdipositasDie Rolle kostimulato-rischer Moleküle

A. Zirlik

¹Atherogenesis Research Group, Heart Center Freiburg University, Cardiology and Angiology I, University of Freiburg, Germany

,

E. Lutgens

²Department of Medical Biochemistry, Experimental Vascular Biology division, Academic Medical Centre, University of Amsterdam, The Netherlands

³Institute for Cardiovascular Prevention, Ludwig Maximilian’s University, Munich, Germany

⁴DZHK German Center for Cardiovascular Research, partner site Munich Heart Alliance, Munich, Germany

› Author Affiliations

Abstract

Summary

Atherosclerosis and obesity-induced metabolic dysfunction are lipid-driven inflammatory pathologies responsible for a major part of cardiovascular complications. Immune cell activation as well as interactions between the different immune cells is dependent on and controlled by a variety of co-stimulatory signals. These co-stimulatory signals can either aggravate or ameliorate the disease depending on the stage of the disease, the cell-types involved and the signal transduction cascades initiated. This review focuses on the diverse roles of the most established co-stimulatory molecules of the B7 and Tumor Necrosis Factor Receptor (TNFR) families, ie the CD28/CTLA4-CD80/CD86 and CD40L/CD40 dyads in the pathogenesis of atherosclerosis and obesity. In addition, we will explore their potential as therapeutic targets in both atherosclerosis and obesity.

Zusammenfassung

Atheroskleroseund Adipositas-induzierte metabolische Dysfunktionen sind lipid-assoziierte, inflammatorische Pathologien, welche für einen großen Teil kardiovaskulärer Komplikationen verantwortlich sind. Die Aktivierung von Immunzellen sowie die Kommunikation verschiedener Immunzellen untereinander sind von einer Vielzahl kostimulatorischer Signale abhängig. Diese kostimulatorischen Signale können den Krankheitsverlauf entweder aggravieren oder verbessern, jeweils in Abhängigkeit von dem Stadium der Erkrankung und den Zelltypen, die involviert sind sowie in Abhängigkeit der Signalkaskaden, welche aktiviert werden. Der folgende Review-Artikel hat die diversen Rollen der bekanntesten Vertreter kostimulatorischer Moleküle der B7 und TumornekrosefaktorRezeptor-Familie, z. B. die CD28/CTLA4-CD80/CD86-Interaktionen und die CD40L/ CD40-Interaktion in der Pathogenese von Atherosklerose und Adipositas zum Schwerpunkt. Darüber hinaus diskutieren wir das Potential kostimulatorischer Signalwege als therapeutisches Ziel in den beiden Krankheitsbildern Atherosklerose und Adipositas.

Keywords

Atherosclerosis - obesity - co-stimulation

Schlüsselwörter

Atherosklerose - Adipositas - Kostimulation

Full Text

References

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