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CC BY-NC-ND 4.0 · World J Nucl Med 2021; 20(04): 411-413
DOI: 10.4103/wjnm.wjnm_5_21
Case Report

18FDG PET-CT in sporadic Creutzfeldt-Jakob disease, correlated with MRI and histology

Nicholas Morley
Department of Radiology, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom
,
Monika Hofer
1   Department of Neuropathology, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom
,
Philip Wilkinson
2   Department of Psychiatry, University of Oxford, Oxford, United Kingdom
,
Kevin Bradley
Department of Radiology, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom
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Abstract

We present a case of sporadic Creutzfeldt–Jakob disease with profoundly abnormal 18fluoro-deoxy-glucose positron emission tomography with computed tomography (FDG PET-CT) at an early stage, and correlate this with the clear findings at magnetic resonance imaging and also postmortem histology. Prion diseases are rare but important causes of cognitive impairment. The role of FDG PET-CT is discussed, along with other investigations such as electroencephalography and cerebro-spinal fluid analyses.

Keywords

Dementia - magnetic resonance imaging - positron emission tomography - prion diseases

Financial support and sponsorship

Nil.




Publication History

Received: 09 February 2021

Accepted: 07 March 2021

Article published online:
24 March 2022

© 2021. Sociedade Brasileira de Neurocirurgia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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