Bone scintigraphy imaging of cardiac amyloidosis

Issa Menge Kuria; Samuel Nguku Gitau; Khalid Bashir Makhdomi

doi:10.4103/wjnm.WJNM_9_19

World Journal of Nuclear Medicine, Table of Contents

CC BY-NC-ND 4.0 · World J Nucl Med 2019; 18(03): 314-316
DOI: 10.4103/wjnm.WJNM_9_19

Case Report

Bone scintigraphy imaging of cardiac amyloidosis

Issa Menge Kuria

Department of Imaging and Diagnostic Radiology, Aga Khan University Hospital, Nairobi, Kenya

,

Samuel Nguku Gitau

Department of Imaging and Diagnostic Radiology, Aga Khan University Hospital, Nairobi, Kenya

,

Khalid Bashir Makhdomi

Department of Imaging and Diagnostic Radiology, Aga Khan University Hospital, Nairobi, Kenya

› Author Affiliations

Abstract

Transthyretin-related cardiac amyloidosis (ATTR) amyloidosis is an aggressive, rapidly progressive, and fatal disease, for which several promising therapies are in development. This condition is frequently underdiagnosed because of the limited specificity of echocardiography and the traditional requirement for histological diagnosis. It is well known that ^99mtechnetium-labeled bone scan radiotracers can localize in the myocardial amyloid deposits, but the use of this imaging modality to differentiate between the two subtypes has only lately been revisited. We report a case of a 76-year-old man with a clinical diagnosis of amyloidosis who underwent a bone scan that had features of ATTR amyloidosis. To the best of our knowledge, this is the first case report in Sub-Saharan Africa.

Keywords

AL - bone scintigraphy - cardiac amyloidosis - transthyretin ATTR

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References

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