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CC BY-NC-ND 4.0 · World J Nucl Med 2018; 17(03): 139-144
DOI: 10.4103/wjnm.WJNM_32_17
Original article

Positron emission tomography-computed tomography for inguinal nodes in vulvar cancer

Jorge Oldan
Department of Radiology, UNC-Chapel Hill Hospitals, Chapel Hill, NC 27599, USA
,
Stephanie Sullivan
Department of Radiology, UNC-Chapel Hill Hospitals, Chapel Hill, NC 27599, USA
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We aimed to determine the sensitivity and specificity of fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET-CT) for the spread of disease to inguinal lymph nodes in vulvar cancer. A retrospective review of vulvar cancer patients who underwent both inguinal nodal sampling and dissection as well as FDG PET-CT was performed, with 21 patients meeting criteria. The sensitivity and specificity of the FDG PET-CT imaging was performed using a combination of maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG). Using an SUVmaxcutoff of 4.5 or of two times the average liver uptake, we had a 100% sensitivity and 89% specificity for positive inguinal nodes. MTV and TLG did not add to sensitivity or specificity. We conclude that FDG PET-CT has good sensitivity for inguinal nodal spread in vulvar cancer, and either a quantitative or semiquantitative approach is effective.

Keywords

Fluorodeoxyglucose positron emission tomography-computed tomography - maximum standardized uptake value - metabolic tumor volume - quantitative imaging - total lesion glycolysis - vulvar cancer


Publication History

Article published online:
17 May 2022

© 2018. Sociedade Brasileira de Neurocirurgia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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