Download PDF
CC BY-NC-ND 4.0 · Libyan International Medical University Journal 2021; 06(02): 91-98
DOI: 10.4103/liuj.liuj_78_21
Original Article

The use of chitosan in the preparation of bioadhesive buccal films: Film-forming ability and sustaining ibuprofen release

Fadia Mussa
Department of Pharmaceutics, Faculty of Pharmacy, University of Tripoli, Tripoli, Libya
,
Haytham Mousi
Department of Pharmaceutics, Faculty of Pharmacy, University of Tripoli, Tripoli, Libya
,
Mahmud Treki
Department of Pharmaceutics, Faculty of Pharmacy, University of Tripoli, Tripoli, Libya
› Author Affiliations
› Further Information
Also available at
  Permissions and Reprints

Abstract

Aim: Different polymers were introduced into Chitosan bioadhesive buccal films to achieve substantial success in sustaining Ibuprofen release for few hours, with reasonable bioadhesion strength. Design: Thin, isolatable, transparent, and elastic films of these copolymers were prepared. Nineteen formulations have been classified as six systems according to the percentages of hydrocolloids used. Materials and Methods: The films were prepared using the solvent casting technique. Bioadhesion study was conducted using the stomach mucosa of a sacrificed albino rabbit. Hydrocolloids such as Hydroxy Propyl Cellulose (HPC), Chitosan, and Methyl Cellulose (MC), in addition to other polymers, were used in addition to Ibuprofen as a model drug. Results: The mechanical strength and flexibility of the films were confirmed with no signs of breaking down. Selected films composed of about 60% (w/w) HPC were found to show higher tendency to adhere to the stomach mucosa than lower percentages of the same polymer. Chitosan films have released more than 78% of Ibuprofen content in the 1st h of release study. The introduction of MC in these films has led to a slow but continuous increase in the percentage of drugs released, reaching the climax of 82% after 4 h. Conclusion: Films made of formulation (L17) were found to be the most ideal for both releasing appreciable amount of drug (about 98% in 4 h), and their high tendency to adhering to the rabbit mucosa (71.00 Mn/m) giving enough time to exert the drug's effect locally. The mechanism of drug release was found to follow Higuchi's diffusion model for some systems and the classical first-order kinetics for others.

Key-words:

Bioadhesive films - cellulose derivatives - chitosan - ibuprofen - mechanism of drug release

Financial support and sponsorship

Nil.




Publication History

Received: 24 June 2021

Accepted: 24 October 2021

Article published online:
14 June 2022

© 2021. Libyan International Medical University. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 

  • References

  • 1 Park JH. Saravanakumar. Targeted delivery of low molecular drugs using Chitosn and its derivatives, Adv. Drug Deliv Rev 2010;(62):28-41.
  • 2 Perugini PI, Conti B, Modena T, Pavanetto F. Periodontal delivery of ipriflavone: New chitosan/PLGA film delivery system for a lipophilic drug. Int J Pharm 2003;252:1-9.
  • 3 Li QM. Application and properities of chitosan, J Bioactcompat Polumer 1992;7:370-97.
  • 4 Khan TA, Kokhianagpeh TO, Sengching H. Mechanical, bioadhesive strength and biological evaluations of chitosan films for wound dressing. J Pharm Pharm Sci 2000;3:303-11.
  • 5 Honary S, Hoseinzadeh B, Shalchian P. The effect of polymer molecular weight on citrate crosslinked chitosan films for site-specific delivery of a non-polar drug. Trop J Pharm Res 2010;9:525-31.
  • 6 Gulzar AM, Charyulu NR, Harish M, Prabhakar M. Formulation and in vitro evaluation of Chitosan films containing tetracycline for the treatment of periodontitis. Asian J Pharm 2009;(9):1-5.
  • 7 Rasoolet BK. Design and evaluation of a bioadhesive films for transdermal delivery of propranolol hydrochloride. Acta Pharm 2011;61:271-82.
  • 8 Ismailova AB. Application of chitosan films for the treatment of age-related macular. Int J Chem Sci 2014;12:1500-8.
  • 9 Senel S, Ikinci G, Kaş S, Yousefi-Rad A, Sargon MF, Hincal AA. Chitosan films and hydrogels of chlorhexidine gluconate for oral mucosal delivery. Int J Pharm 2000;193:197-203.
  • 10 Janes KA, Calvo P, Alonso MJ. Polysaccharide colloidal particles as delivery systems for macromolecules. Adv Drug Deliv Rev 2001;47:83-97.
  • 11 Noyes A, Whitney W. Dissolution theory. J Am Chem Soc 1897;23:689.
  • 12 Khairnar A, Jain P, Baviskar D, Jain D. Development of mucoadhesive buccal patch containing aceclofenac in vitro evaluations. Int J Pharm Tech Res 2009;1:978-81.
  • 13 Alagusundaram M, Chengaiah B, Ramkanth S, Angalaparameswari S, Chetty SM. Formulation andevaluation of mucoadhesive buccal film of ranitidine. Int J Pharm Tech Res 2009;1:557-63.
  • 14 Gibaldi M, Perrier D. Statistical methods for population pharmacokinetic modeling. In: Drugs and the Pharmaceutical Sciences. 2nd ed. New York and Basel: MarcelDekker, Inc.,; 1982.
  • 15 Higuchi T. Mechanism of sustained medication, Theoretical analysis of rate of release of solid drugs dispersed in solid matrices. J Pharm Sci 1963;84:1464-77.
  • 16 Gorle A, Patil P, Bhaskar R, Ola M. Development and evaluation of buccal film containing antihypertensive agent. Pharm Innov J 2015;4:53-60.
  • 17 Shao Y, Li L, Gu X. Wang L, Mao S. Ionic polymers based tablets for water-soluble drugs. Asian J Pharm Sci 2015;10:20-9.
  • 18 Patel VM, Prajapati G, Patelv M. Design and characterization of Chitosan-containing mucoadhesive buccal patches of propranolol hydrochloride. Acta Pharm 2007;57:61-72.
  • 19 Nasatto PL, Pignon F, Joana LM, Silveira MS, Eugênia MR, Duarte KL, et al. Methylcellulose, a cellulose derivative with original physical Properties and extended applications, Review. Polymers 2015;7:777-803.
  • 20 Nafeeet NA. Design and characterization of mucoadhesivebuccal patches containing cetylpyridinium chloride. Acta Pharm 2003;53:199-212.
  • 21 Enayatifard R, Saeedi M, Akbari J, Tabatabaee HY. Effect of hydroxypropyl methylcellulose and ethylcellulose content on release profile and kinetics of diltiazem HCl from matrices. Trop J Pharm Res 2009;8:4-5.
  • 22 Henriksen I, Green KL, Smart JD, Smistad G, Karlsen J. Bioadhesion of hydrated Chitosans: An in vitro and in vivo study. Int J Pharm 1996;145:231-40.
  • 23 Christina D, Sajeeth CI. Design, development and evaluation of mucoadhesive patches of Repaglinide for bucal delivery. IJPT 2013;5:5271-88.
  • 24 Naresh K, Naresh T, Sushama M, Gopal M. Designe and evaluation of mucoadhesive buccal patch of Floxutin Hcl. Int J Sci Res Publ 2012;2:132-41.
  • 25 Borodkin S, Tucker FE. Linear drug release from laminated hydroxypropyl cellulose-polyvinyl acetate films. J Pharm Sci 1974;63:1359-64.
  • 26 Samuelov Y, Donbrow M, Friedman M. Sustained release of drugs from ethylcellulose--polyethylene glycol films and kinetics of drug release. 100Ibid; 1979; 68:325-6.
  • 27 Higuchi T. Mechanism of sustained-action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices. J Pharm Sci 1963;52:1145-9.