CC BY-NC-ND 3.0 · Journal of Digestive Endoscopy 2017; 08(04): 182-186
DOI: 10.4103/jde.JDE_33_17
Original Article
Journal of Digestive Endoscopy

Clinical Outcome of Pneumatic Dilatation in Patients with Achalasia Cardia: A Single-Center Prospective Study

Amit Hanmant Shejal
Department of Gastroenterology, Government Medical College, Kozhikode, Kerala, India
,
Thazhath Mavali Ramachandran
,
Sunil Kumar N
Department of Gastroenterology, Government Medical College, Kozhikode, Kerala, India
› Institutsangaben
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
25. September 2019 (online)

ABSTRACT

Background and Aim: Pneumatic balloon dilation is one of the most commonly used and effective methods for treating patients with achalasia cardia. This study was performed to assess immediate and long-term response of pneumatic dilatation (PD) in these patients. Materials and Methods: Forty-four achalasia cardia patients, who underwent PD in our center from January 2013 to December 2015, were prospectively studied. Data from these patients were analyzed for clinical improvement in symptoms after dilatation procedure over this period as per Eckardt score. Patients who required repeated procedure and factors influencing remission of symptoms were analyzed. Results: A total of 44 patients underwent PD, among which three lost to follow up. Of the 41 patients, 21 were male (51.22%) and 20 were females (48.78%). Mean age was 38.68 (13–64) years. Median symptom duration before first dilatation was 18 months (2–240). Major symptoms at presentation were dysphagia (n = 41, 100%), regurgitation (n = 38 92.68%), chest pain (n = 31, 75.6%), and weight loss (n = 20, 48.78%). Mean follow-up period was 22.22 months (9–38). Forty (97.56%) patients had immediate clinical improvement after 1 dilatation, of which 38 (92.68%) patients did not require any further treatment. Mean Eckardt score was 6.82 (4–11) at the time of first dilatation which improved to 0.66 during follow-up. Two patients required second dilatation (one 5 months and other 18 months after the first procedure). Conclusion: PD is a safe and effective long-term therapy for achalasia cardia and has a good long-term clinical remission.

 
  • References

  • 1 Ghoshal UC, Daschakraborty SB, Singh R. Pathogenesis of achalasia cardia. World J Gastroenterol 2012; 18: 3050-7
  • 2 Park W, Vaezi MF. Etiology and pathogenesis of achalasia: The current understanding. Am J Gastroenterol 2005; 100: 1404-14
  • 3 Boeckxstaens GE, Zaninotto G, Richter JE. Achalasia. Lancet 2014; 383: 83-93
  • 4 Richter JE, Boeckxstaens GE. Management of achalasia: Surgery or pneumatic dilation. Gut 2011; 60: 869-76
  • 5 Youn YH, Minami H, Chiu PW, Park H. Peroral endoscopic myotomy for treating achalasia and esophageal motility disorders. J Neurogastroenterol Motil 2016; 22: 14-24
  • 6 Boeckxstaens GE, Annese V, des Varannes SB, Chaussade S, Costantini M, Cuttitta A. et al. Pneumatic dilation versus laparoscopic Heller’s myotomy for idiopathic achalasia. N Engl J Med 2011; 364: 1807-16
  • 7 Ghoshal UC, Kumar S, Saraswat VA, Aggarwal R, Misra A, Choudhuri G. et al. Long-term follow-up after pneumatic dilation for achalasia cardia: Factors associated with treatment failure and recurrence. Am J Gastroenterol 2004; 99: 2304-10
  • 8 Zerbib F, Thetiot V, Richy F, Benajah DA, Message L, Lamouliatte H. et al. Repeated pneumatic dilations as long-term maintenance therapy for esophageal achalasia. Am J Gastroenterol 2006; 101: 692-7
  • 9 Eckardt VF. Clinical presentations and complications of achalasia. Gastrointest Endosc Clin N Am 2001; 11: 281-92 vi
  • 10 Vaezi MF, Richter JE. Diagnosis and management of achalasia. American college of gastroenterology practice parameter committee. Am J Gastroenterol 1999; 94: 3406-12
  • 11 Pandolfino JE, Fox MR, Bredenoord AJ, Kahrilas PJ. High-resolution manometry in clinical practice: Utilizing pressure topography to classify oesophageal motility abnormalities. Neurogastroenterol Motil 2009; 21: 796-806
  • 12 Vela MF, Richter JE, Khandwala F, Blackstone EH, Wachsberger D, Baker ME. et al. The long-term efficacy of pneumatic dilatation and heller myotomy for the treatment of achalasia. Clin Gastroenterol Hepatol 2006; 4: 580-7
  • 13 Katsinelos P, Kountouras J, Paroutoglou G, Beltsis A, Zavos C, Papaziogas B. et al. Long-term results of pneumatic dilation for achalasia: A 15 years’ experience. World J Gastroenterol 2005; 11: 5701-5
  • 14 Chuah SK, Hu TH, Wu KL, Hsu PI, Tai WC, Chiu YC. et al. Clinical remission in endoscope-guided pneumatic dilation for the treatment of esophageal achalasia: 7-year follow-up results of a prospective investigation. J Gastrointest Surg 2009; 13: 862-7
  • 15 Mehta R, John A, Sadasivan S, Mustafa CP, Nandkumar R, Raj VV. et al. Factors determining successful outcome following pneumatic balloon dilation in achalasia cardia. Indian J Gastroenterol 2005; 24: 243-5
  • 16 Karamanolis G, Sgouros S, Karatzias G, Papadopoulou E, Vasiliadis K, Stefanidis G. et al. Long-term outcome of pneumatic dilation in the treatment of achalasia. Am J Gastroenterol 2005; 100: 270-4
  • 17 West RL, Hirsch DP, Bartelsman JF, de BorstJ, Ferwerda G, Tytgat GN. et al. Long term results of pneumatic dilation in achalasia followed for more than 5 years. Am J Gastroenterol 2002; 97: 1346-51
  • 18 Pratap N, Kalapala R, Darisetty S, Joshi N, Ramchandani M, Banerjee R. et al. Achalasia cardia subtyping by high-resolution manometry predicts the therapeutic outcome of pneumatic balloon dilatation. J Neurogastroenterol Motil 2011; 17: 48-53
  • 19 Rohof WO, Salvador R, Annese V, Bruley des VarannesS, Chaussade S, Costantini M. et al. Outcomes of treatment for achalasia depend on manometric subtype. Gastroenterology 2013; 144: 718-25