A Man with Diarrhea

ABSTRACT

Diarrhea, a common presenting complaint which we come across in our day‑to‑day practice, is often self‑limited but can be challenging at times. Here, we report one such patient. A 54‑year‑old male presented with diarrhea, abdominal pain, anorexia, and weight loss. Routine blood and stool examination was not helpful. A colonoscopy done elsewhere showed a fistulous opening in the anal canal for which he underwent a fistulectomy. Esophagogastroduodenoscopy revealed severe esophagitis, multiple duodenal ulcers, and a fundic gland polyp from which biopsies were taken. The fundic gland polyp showed oxyntic gland hyperplasia. Basal acid output and serum fasting gastrin subsequently measured were also high. A diagnosis of Zollinger–Ellison syndrome was made, and the patient was started on high‑dose proton‑pump inhibitors, to which he had excellent response. Repeat endoscopy showed resolutions of all lesions. Endoscopic ultrasound (EUS) and DOTA (Gallium (68Ga) DOTA-TATE) scan revealed a tumor in the duodenum and pylorus, respectively. On surgical exploration, the tumor was identified in the second part of the duodenum and was removed. The patient has remained asymptomatic since then.

Keywords

Basal acid output - chronic diarrhea - Zollinger–Ellison syndrome

Publikationsverlauf

Publikationsdatum:
24. September 2019 (online)

• References

• 1 Modlin IM, Lye KD, Kidd M. A 5 decade analysis of 13,715 carcinoid tumors. Cancer 2003; 97: 934-59
• 2 Nandy N, Hanson JA, Strickland RG, McCarthy DM. Solitary gastric carcinoid tumor associated with long term use of omeprazole: A Case report and review of the literature. Dig Dis Sci 2016; 61: 708-12
• 3 Rehfeld JF, Bardram L, Hilsted L, Poitras P, Goetze JP. Pitfallsin diagnostic gastrin measurements. Clin Chem 2012; 58: 831-6
• 4 Ghosh T, Lewis DI, Axon AT, Everett SM. Review article: Methods of measuring gastric acid secretion. Aliment Pharmacol Ther 2011; 33: 768-81
• 5 Delle Fave G, O'Toole D, Sundin A, Taal B, Ferolla P, Ramage JK. et al. ENETS consensus guidelines update for gastroduodenal neuroendocrine neoplasms. Neuroendocrinology 2016; 103: 119-24