CC BY-NC-ND 4.0 · Indian J Radiol Imaging 2021; 31(S 01): S61-S69
DOI: 10.4103/ijri.IJRI_965_20
Original Article

The value of AI based CT severity scoring system in triage of patients with Covid-19 pneumonia as regards oxygen requirement and place of admission

Anirudh Kohli
Departments of Imaging and Critical Care, Breach Candy Hospital Trust, Breach Candy, Cumballa Hill, Mumbai, Maharashtra, India
,
Tanya Jha
Departments of Critical Care, Breach Candy Hospital Trust, Breach Candy, Cumballa Hill, Mumbai, Maharashtra, India
,
Amal Babu Pazhayattil
Departments of Imaging and Critical Care, Breach Candy Hospital Trust, Breach Candy, Cumballa Hill, Mumbai, Maharashtra, India
› Author Affiliations
Financial support and sponsorship Nil.

Abstract

Context: CT scan is a quick and effective method to triage patients in the Covid-19 pandemic to prevent the heathcare facilities from getting overwhelmed. Aims: To find whether an initial HRCT chest can help triage patient by determining their oxygen requirement, place of treatment, laboratory parameters and risk of mortality and to compare 3 CT scoring systems (0-20, 0-25 and percentage of involved lung models) to find if one is a better predictor of prognosis than the other. Settings and Design: This was a prospective observational study conducted at a Tertiary care hospital in Mumbai, Patients undergoing CT scan were included by complete enumeration method. Methods and Material: Data collected included demographics, days from swab positivity to CT scan, comorbidities, place of treatment, laboratory parameters, oxygen requirement and mortality. We divided the patients into mild, moderate and severe based on 3 criteria - 20 point CT score (OS1), 25 point CT score (OS2) and opacity percentage (OP). CT scans were analysed using CT pneumonia analysis prototype software (Siemens Healthcare version 2.5.2, Erlangen, Germany). Statistical Analysis: ROC curve and Youden’s index were used to determine cut off points. Multinomial logistic regression used to study the relations with oxygen requirement and place of admission. Hosmer-Lemeshow test was done to test the goodness of fit of our models. Results: A total of 740 patients were included in our study. All the 3 scoring systems showed a significant positive correlation with oxygen requirement, place of admission and death. Based on ROC analysis a score of 4 for OS1, 9 for OS2 and 12.7% for OP was determined as the cut off for oxygen requirement. Conclusions: CT severity scoring using an automated deep learning software programme is a boon for determining oxygen requirement and triage. As the score increases, the chances of requirement of higher oxygen and intubation increase. All the three scoring systems are predictive of oxygen requirement.



Publication History

Received: 24 December 2020

Accepted: 05 January 2021

Article published online:
13 July 2021

© 2021. Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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  • References

  • 1 Available from: https://www.who.int. [Last accessed on 2020 Dec 22].
  • 2 Cavallo J, Donoho D, Forman H. Hospital capacity and operations in the coronavirus disease 2019 (COVID-19) pandemic—Planning for the Nth Patient. JAMA Health Forum 2020. doi: 10.1001/jamahealthforum.2020.0345.
  • 3 Udugama B, Kadhiresan P, Kozlowski H, Malekjahani A, Osborne M, Li V. et al. Diagnosing COVID-19: The disease and tools for detection. ACS Nano 2020; 14: 3822-35
  • 4 Guan W, Ni Z, Liang W, Ou C, He J, Liu L. et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med 2020; 382: 1708-20
  • 5 Borczuk A, Salvatore S, Surya S, Patel S, Bussel J, Mostyka M. et al. COVID-19 pulmonary pathology: A multi-institutional autopsy cohort from Italy and New York City. Mod Pathol 2020; 33: 2156-68
  • 6 Pan F, Ye T, Gui S, Sun P, Liang B, Zheng D. et al. Time course of lung changes at chest CT during recovery from coronavirus disease 2019 (COVID-19). Radiology 2020; 295: 715-21
  • 7 Wasilewski P, Mruk B, Mazur S, Szymczak G, Sklinda K, Walecki J. COVID-19 severity scoring systems in radiological imaging-A review. Pol J Radiol 2020; 85: e361-8
  • 8 Liu J, Chen T, Yang H, Cai Y, Yu Q, Chen J. et al. Clinical and radiological changes of hospitalised patients with COVID-19 pneumonia from disease onset to acute exacerbation: A multicenter paired cohort study. Eur Radiol 2020; 30: 5702-8
  • 9 Francone M, Lafrate F, Masci G, Coco S, Cilia F, Manganaro L. et al. Chest CT score in COVID-19 patients: Correlation with disease severity and short-term prognosis. Eur Radiol 2020; 30: 6808-17
  • 10 Yang R, Li X, Liu H, Zhen Y, Zhang X, Xiong Q. et al. Chest CT severity score: An imaging tool for assessing severe COVID-19. Radiol Cardiothoracic Imaging 2020; 2: e200047
  • 11 Yuan M, Yin W, Tao Z, Tan W, Hu Y. Association of radiologic findings with mortality of patients infected with 2019 novel coronavirus in Wuhan, China. PLoS One 2020; 15: e0230548 DOI: 10.1371/journal.pone.0230548.
  • 12 Li K, Fang Y, Li W, Pan C, Qin P, Zhong Y. et al. CT image visual quantitative evaluation and clinical classification of coronavirus disease (COVID-19). Eur Radiol 2020; 30: 4407-16
  • 13 Huang L, Han R, Ai T, Yu P, Kang H, Tao Q. et al. Serial quantitative chest CT assessment of COVID-19: A deep learning approach. Radiol Cardiothorac Imaging 2020; 2: e200075 DOI: 10.1148/ryct.2020200075.
  • 14 Zhang J, Meng G, Li W, Shi B, Dong H, Su Z. et al. Relationship of chest CT score with clinical characteristics of 108 patients hospitalized with COVID-19 in Wuhan, China. Respir Res 2020; 21: 180
  • 15 Lanza E, Muglia R, Bolengo I, Santonocito O, Lisi C, Angelotti G. et al. Quantitative chest CT analysis in COVID-19 to predict the need for oxygenation support and intubation. Eur Radiol 2020; 30: 6770-8
  • 16 Colombi D, Bodini F, Petrini M, Maffi G, Morelli N, Milanese G. et al. Well-aerated lung on admitting chest CT to predict adverse outcome in COVID-19 pneumonia. Radiology 2020; 296: E86-7
  • 17 Leonardi A, Scipione R, Alfieri G, Petrillo R, Dolciami M, Ciccarelli F. et al. Role of computed tomography in predicting critical disease in patients with covid-19 pneumonia: A retrospective study using a semiautomatic quantitative method. Eur J Radiol 2020; 130: 109202
  • 18 Kimura-Sandoval Y, Arévalo-Molina ME, Cristancho-Rojas CN, Kimura-Sandoval Y, Rebollo-Hurtado V, Licano-Zubiate M. et al. Validation of chest computed tomography artificial intelligence to determine the requirement for mechanical ventilation and risk of mortality in hospitalized coronavirus disease-19 patients in a tertiary care center In Mexico City. Rev Invest Clın 2020. doi: 10.24875/RIC.20000451.
  • 19 Tabatabaei S, Rajebi H, Moghaddas F, Ghasemiadl M, Talari H. Chest CT in COVID-19 pneumonia: What are the findings in mid-term follow-up?. Emerg Radiol 2020; 27: 711-9
  • 20 Lyu P, Liu X, Zhang R, Shi L, Gao J. The performance of chest CT in evaluating the clinical severity of COVID-19 pneumonia: Identifying critical cases based on CT characteristics. Invest Radiol 2020; 55: 412-21
  • 21 Saeed G, Gaba W, Shah A, Helali A, Raidullah E, Ali A. et al. Correlation between Chest CT severity scores and the clinical parameters of adult patients with COVID-19 pneumonia. medRxiv 2020. doi: 10.1101/2020.10.15.20213058.
  • 22 Mahdjoub E, Mohammad W, Lefevre Debray MP, Khalil A. Study Group§. Admission chest CT score predicts 5-day outcome in patients with COVID-19. Intensive Care Med 2020; 46: 1648-50
  • 23 Zhou S, Chengyang C, Hu Y, Lv W, Ai T, Xia L. Chest CT imaging features and severity scores as biomarkers for prognostic prediction in patients with COVID-19. Ann Transl Med 2020; 8: 1449 DOI: 10.21037/atm-20-3421.
  • 24 Feng Z, Yu Q, Yao S, Luo L, Duan J, Yan Z. et al. Early prediction of disease progression in COVID-19 pneumonia patients with chest CT and clinical characteristics. Nat Commun 2020; 11: 4968 DOI: 10.1038/s41467-020-18786-x.
  • 25 Abbasi B, Akhavan R, Ghamari Khameneh A, Zandi B, Farrokh D, Pezeshki Rad M. et al. Evaluation of the relationship between inpatient COVID-19 mortality and chest CT severity score. Am J Emerg Med 2020; S0735-6757 (20) 30851-2 DOI: 10.1016/j.ajem.2020.09.056.