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CC BY-NC-ND 4.0 · Indian J Radiol Imaging 2018; 28(04): 427-432
DOI: 10.4103/ijri.IJRI_84_18
Cardiac

Myocardial nulling pattern in cardiac amyloidosis on time of inversion scout magnetic resonance imaging sequence – A new observation of temporal variability

Harshavardhan Mahalingam
Departments of Radiology, Christian Medical College, Vellore, Tamil Nadu, India
,
Binita Riya Chacko
Departments of Radiology, Christian Medical College, Vellore, Tamil Nadu, India
,
Aparna Irodi
Departments of Radiology, Christian Medical College, Vellore, Tamil Nadu, India
,
Elizabeth Joseph
Departments of Radiology, Christian Medical College, Vellore, Tamil Nadu, India
,
Leena R Vimala
Departments of Radiology, Christian Medical College, Vellore, Tamil Nadu, India
,
Viji Samuel Thomson
Departments of Cardiology, Christian Medical College, Vellore, Tamil Nadu, India
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Abstract

Context: The pattern of myocardial nulling in the inversion scout sequence [time of inversion scout (TIS)] of cardiac magnetic resonance imaging (MRI) is an accurate tool to detect cardiac amyloidosis. The pattern of nulling of myocardium and blood at varying times post gadolinium injection and its relationship with left ventricular mass (LVM) in amyloidosis have not been described previously. Aims: The aim is to study the nulling pattern of myocardium and blood at varying times in TIS and assess its relationship with LVM and late gadolinium enhancement (LGE) in amyloidosis. Materials and Methods: This was a retrospective study of 109 patients with clinical suspicion of cardiac amyloidosis who underwent MRI. Of these, 30 had MRI features of amyloidosis. The nulling pattern was assessed at 5 (TIS5min) and 10 (TIS10min) minutes (min) post contrast injection. Nulling pattern was also assessed at 3min (TIS3min) in four patients and 7min (TIS7min) in five patients. Myocardial mass index was calculated. Mann-Whitney U test was done to assess statistical difference in the myocardial mass index between patients with and without reversed nulling pattern (RNP) at TIS5min. Results: RNP was observed in 58% at TIS5minand 89.6% at TIS10min. Myocardial mass index was significantly higher in patients with RNP at TIS5min[mean = 94.87 g/m2; standard deviation (SD) =17.63) when compared with patients with normal pattern (mean = 77.61 g/m2; SD = 17.21) (U = 18; P = 0.0351). Conclusion: In cardiac amyloidosis, TIS sequence shows temporal variability in nulling pattern. Earlier onset of reverse nulling pattern shows a trend toward more LVM and possibly more severe amyloid load.

Keywords

Amyloidosis - cardiac - magnetic resonance imaging - TI scout


Publication History

Article published online:
26 July 2021

© 2018. Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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