CC BY-NC-ND 4.0 · Indian J Radiol Imaging 2018; 28(04): 460-464
DOI: 10.4103/ijri.IJRI_488_17
Endocrine (Thyroid, Adrenal, Breast)

Differentiation between benign and malignant thyroid nodules using diffusion-weighted imaging, a 3-T MRI study

Leila Aghaghazvini
Department of Radiology, Shariati Hospital, Tehran, Iran
,
Hashem Sharifian
Department of Radiology, Amir Alam Hospital, Tehran University of Medical Sciences, Tehran, Iran
,
Nasrin Yazdani
Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran
,
Melina Hosseiny
Department of Radiology, Shariati Hospital, Tehran, Iran
,
Saina Kooraki
Department of Radiology, Shariati Hospital, Tehran, Iran
,
Pirouz Pirouzi
Department of Radiology, Shariati Hospital, Tehran, Iran
,
Afsoon Ghadiri
Department of Radiology, Shariati Hospital, Tehran, Iran
,
Madjid Shakiba
Advanced Diagnostic and Interventional Radiologic Research Center (ADIR), Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
,
Soheil Kooraki
Department of Radiology, Shariati Hospital, Tehran, Iran
› Author Affiliations

Subject Editor: Financial support and sponsorship Nil.

Abstract

Background: Preoperative differentiation of benign from malignant thyroid nodules remains a challenge. Aims: This study assessed the accuracy of diffusion-weighted imaging (DWI) for differentiation between benign and malignant thyroid nodules. Materials and Methods: Preoperative DWI was performed in patients with thyroid nodule by means of a 3-T scanner magnetic resonance imaging (MRI). Images were obtained at b value of 50, 500, and 1000 mm2/s to draw an ADC (apparent diffusion coefficient) map. Findings were compared with postoperative histopathologic results. Receiver operating characteristic curve was used to assess the accuracy of different cutoff points. Results: Forty-one thyroid nodules (26 benign and 15 malignant) were included in this study. None of static MRI parameters such as signal intensity, heterogeneity, and nodule border was useful to discriminate between benign and malignant lesions. Mean ADC value was (1.94 ± 0.54) × 10−3 mm2/s and (0.89 ± 0.29) × 10−3 mm2/s in benign and malignant nodules, respectively (P-value < 0.005). ADC value cutoff of 1 × 10−3 mm2/s yielded an accuracy, sensitivity, and specificity of 93%, 87%, and 96% to discriminate benign and malignant nodules. Conclusion: DWI is highly accurate for discrimination between benign and malignant thyroid nodules.



Publication History

Publication Date:
26 July 2021 (online)

© 2018. Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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