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CC BY-NC-ND 4.0 · Indian J Radiol Imaging 2020; 30(02): 222-224
DOI: 10.4103/ijri.IJRI_486_19
Case Report

Anti-myelin oligodendrocyte glycoprotein antibody-positive coursing with optic neuritis: Imaging and clinical implications

Nithisha Thatikonda
Medical Student, GMC Nagpur, MUHS, India
,
Juan Gomez
Radiology Research Fellow, Louisiana State University Health Science Centre, Shreveport, USA
,
Eduardo Gonazalez Toledo
Department of Radiology, Louisiana State University Health Science Centre, Shreveport, USA
› Author Affiliations Financial support and sponsorship Nil.
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Abstract

A 9-year-old boy was admitted to our institution with acute onset of bilateral blurry vision. Physical examination revealed bilateral papilledema. Cerebrospinal fluid analysis and comprehensive metabolic panel were normal. Magnetic resonance imaging (MRI) of the brain showed extensive bilateral optic nerve inflammation with post-contrast gadolinium enhancement on T1-weighted sequence. The involvement was limited to the anterior segments of the optic nerves sparing chiasma and optic tracts. Anti-aquaporin-4 antibody (AQP4) was negative while anti-myelin oligodendrocyte glycoprotein antibody (MOG) was positive. After intravenous methylprednisolone, his vision dramatically improved. The patient was discharged with only mildly impaired visual acuity, 2 weeks after admission. Follow-up brain MRI and MOG assay after 3 months were within normal limits.

Keywords

MRI - myelin oligodendrocyte glycoprotein - optic neuritis


Publication History

Received: 07 December 2019

Accepted: 05 March 2020

Article published online:
19 July 2021

© 2020. Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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