Myriad of MR imaging phenotypes of primary central nervous system lymphoma in a cohort of immunocompetent Indian patient population

Abstract

PCNSL (primary central nervous system lymphoma) is a chemosensitive and radiosensitive tumor, and early diagnosis has a significant impact on management. Unlike many other brain tumors, radical surgical excision of PCNSLs is not indicated because these lesions are highly infiltrative and even partial resection leads to a bad prognosis. The goal of this study is to highlight the unusual radiological presentation of PCNSLs and increase the awareness, familiarity, and global database of our observations that pose a challenge on management.

Keywords

Atypical - MRI - primary central nervous system lymphoma - unusual

Publikationsverlauf

Artikel online veröffentlicht:
26. Juli 2021

• References

• 1 Sharma MC, Gupta RK, Kaushal S, Suri V, Sarkar C, Singh M. et al. A clinicopathological study of primary central nervous system lymphomas & their association with Epstein-Barr virus. Indian J Med Res 2016; 143: 605-15
• 2 Deckert M, Paulus W. Malignant lymphomas. In: Louis DN, Ohgaki H, Wiestler OD, Cavenee WB. editors WHO Classification of Tumours of the Central Nervous System. Lyon, France: International Agency for Research on Cancer; 2007. 4. 188-92
• 3 Tandon A, Challa S, Shanmugam M, Gopalan S, Paul RT, Digumarthi R. et al. Epstein-Barr virus as a possible etiologic agent in primary central nervous system lymphoma in immunocompetent individuals. Neurol India 2009; 57: 36-40
• 4 Abrey LE, Ben-Porat L, Panageas KS, Yahalom J, Berkey B, Curran W. et al. Primary central nervous system lymphoma: The memorial Sloan-Kettering cancer center prognostic model. J Clin Oncol 2006; 24: 5711-5
• 5 Zhang D, Hu LB, Henning TD, Ravarani EM, Zou LG, Feng XY. et al. MRI findings of primary CNS lymphoma in 26 immunocompetent patients. Korean J Radiol 2010; 11: 269-77
• 6 Haldorsen IS, Espeland A, Larsson EM. Central nervous system lymphoma: Characteristic findings on traditional and advanced imaging. AJNR Am J Neuroradiol 2011; 32: 984-92
• 7 Mansour A, Qandeel M, Abdel-Razeq H, Ali HA.Abu. MR imaging features of intracranial primary CNS lymphoma in immune competent patients. Cancer Imaging 2014; 14: 22
• 8 Choi CY, Lee CH, Joo M. Lymphomatosis cerebri. J Korean Neurosurg Soc 2013; 54: 420-2
• 9 Baehring JM, Henchcliffe C, Ledezma CJ, Fulbright R, Hochberg FH. Intravascular lymphoma: Magnetic resonance imaging correlates of disease dynamics within the central nervous system. J Neurol Neurosurg Psychiatry 2005; 76: 540-4
• 10 Lagarde S, Tabouret E, Matta M, Franques J, Attarian S, Pouget J. et al. Primary neurolymphomatosis diagnosis and treatment: A retrospective study. J Neurol Sci 2014; 342: 178-81
• 11 Sen HN, Bodaghi B, Hoang PL, Nussenblatt R. Primary intraocular lymphoma: Diagnosis and differential diagnosis. Ocul Immunol Inflamm 2009; 17: 133-41
• 12 Iwamoto FM, Abrey LE. Primary dural lymphomas: A review. Neurosurg Focus 2006; 21: E5
• 13 Slone HW, Blake JJ, Shah R, Guttikonda S, Bourekas EC. CT and MRI findings of intracranial lymphoma. AJR Am J Roentgenol 2005; 184: 1679-85
• 14 Reni M, Ferreri AJ, Garancini MP, Villa E. Therapeutic management of primary central nervous system lymphoma in immunocompetent patients: Results of a critical review of the literature. Ann Oncol 1997; 8: 227-34
• 15 Schabet M. Epidemiology of primary CNS lymphoma. J Neurooncol 1999; 43: 199-201
• 16 Ali Fazeli M, Janamiri Z, Zali A, Seddighi A, Ashrafi F, Asadi N. MRI findings of primary CNS lymphoma in 20 patients of stereotaxic ward. Int Clin Neurosci J 2016; 3: 158-63