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CC BY-NC-ND 4.0 · Indian J Radiol Imaging 2018; 28(02): 146-151
DOI: 10.4103/ijri.IJRI_211_17
Neuroradiology & Head and Neck Imaging

Language lateralization in pre-adolescent children: FMRI study using visual verb generation and word pair paradigms

Ruma M Sreedharan
Department of Radiology, Government Medical College Hospital, Trivandrum, Kerala, India
,
Jija S James
Departments of Imaging Sciences and Interventional Radiology, Sree Chitra Thirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India
,
Chandrasekharan Kesavadas
Departments of Imaging Sciences and Interventional Radiology, Sree Chitra Thirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India
,
Sanjeev V Thomas
Departments of Imaging Sciences and Interventional Neurology, Sree Chitra Thirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India
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Abstract

Background: FMRI is a noninvasive tool for mapping language networks, especially in children. We conducted FMRI studies in children in the age group 8- 12 years using 2 different paradigms for assessing language networks and lateralization. Aim: To map language networks in pre-adolescent children and to calculate lateralization index using two different visual paradigms. Methods and Materials: The study was conducted in normal right handed children in the age group 8-12 years. Sixteen normal subjects underwent FMRI using 2 paradigms- visual verb generation (VVG), word pairs paradigm (WPP) to stimulate language areas. FMRI data analysis was done using SPM8 (statistical parametric Mapping) software. Total activated voxels were calculated for each hemispheres in the pre-defined ROIs for both paradigms. Results: FMRI showed left language lateralization in 13 out of 16 children with both VVG and WPP and bilateral language lateralization in two subjects. With VVG there was more significant activation in the left inferior triangular gyrus (ITG) (P < 0.001), left inferior opercular gyrus (IOG) (P < 0.01), left middle frontal gyrus (MFG) (P < 0.05), left and right dorsolateral prefrontal cortex (P < 0.05). Left posterior superior temporal gyrus (STG or WA) (P < 0.001), Left AG (P < 0.03), Left SMG (P < 0.05) were significantly activated with WP paradigm. Conclusion: Our FMRI studies showed that VGP predominantly activated frontal language areas and WPP predominantly activated temperoparietal language areas. Several other brain regions were also involved in language processing apart from the classical language areas.

Keywords

Functional magnetic resonance imaging - language lateralization - pre-adolescent children


Publikationsverlauf

Artikel online veröffentlicht:
26. Juli 2021

© 2018. Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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