Download PDF
CC BY-NC-ND 4.0 · Indian J Radiol Imaging 2020; 30(01): 46-51
DOI: 10.4103/ijri.IJRI_209_19
Neuroimaging

Correlation between MRI characteristics of medulloblastoma with histopathological subtypes and 2-year survival

Intan Zariza Hussain
Departments of Radiology, Universiti Kebangsaan Malaysia Medical Center, Jalan Yaacob Latiff, 56000 Cheras, Kuala Lumpur, Malaysia
,
Faizah Mohd Zaki
Departments of Radiology, Universiti Kebangsaan Malaysia Medical Center, Jalan Yaacob Latiff, 56000 Cheras, Kuala Lumpur, Malaysia
,
Shahizon Azura Mukari
Departments of Radiology, Universiti Kebangsaan Malaysia Medical Center, Jalan Yaacob Latiff, 56000 Cheras, Kuala Lumpur, Malaysia
,
Suria Hayati Md Pauzi
Departments of Pathology, Universiti Kebangsaan Malaysia Medical Center, Jalan Yaacob Latiff, 56000 Cheras, Kuala Lumpur, Malaysia
,
C-Khai Loh
Departments of Pediatrics, Universiti Kebangsaan Malaysia Medical Center, Jalan Yaacob Latiff, 56000 Cheras, Kuala Lumpur, Malaysia
,
Hamidah Alias
Departments of Pediatrics, Universiti Kebangsaan Malaysia Medical Center, Jalan Yaacob Latiff, 56000 Cheras, Kuala Lumpur, Malaysia
› Author Affiliations Financial support and sponsorship Nil.
› Further Information
   Permissions and Reprints

Abstract

Objectives: The objective of this study is to describe the imaging features of medulloblastoma (MB) and correlate the MR characteristics with the different histological subtype of MB with 2-year survival. Materials and Methods: This is a retrospective descriptive study. A total of 29 patients diagnosed with MB from January 2005 to December 2015 were included in this study. The MRI brain and spine studies of these patients were retrieved and reviewed by a pediatric radiologist and a neuroradiologist independently, both blinded from the histological type of the MB. The HPE slides were also retrieved and reviewed by a pathologist. Results: 80% of desmoplastic MB showed the presence of intracranial leptomeningeal seeding and 57.1% of anaplastic MB showed the presence of necrosis. The presence of intracranial leptomeningeal seeding (P = 0.002) and necrosis (P = 0.019) was predictive of the histological subtypes. There is a significant correlation between the enhancement pattern and the 2-year outcome (P = 0.03) with 6 out of 8 patients whose tumors showed minimal enhancement having disease progression within 2 years. A significant correlation was also seen between the presence of necrosis with a poorer outcome (P = 0.03) and between the HPE subtype and 2-year outcome (P = 0.03) with anaplastic MB having the poorest prognosis. Conclusion: MR imaging features of intracranial leptomeningeal seeding and the presence of necrosis were correlated with a specific histologic subtype of MB. The enhancement pattern as well as necrosis correlated with 2-year poorer outcome of the disease.

Keywords

Medulloblastoma - MRI - survival


Publication History

Received: 07 May 2019

Accepted: 17 January 2020

Article published online:
19 July 2021

© 2020. Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

Thieme Medical and Scientific Publishers Private Ltd.
A-12, Second Floor, Sector -2, NOIDA -201301, India

 

  • References

  • 1 Fruehwald-Pallamar J, Puchner SB, Rossi A, Garre ML. Magnetic resonance imaging spectrum of medulloblastoma. Neuroradiology 2011; 53: 387-96
    CrossrefPubMedGoogle Scholar
  • 2 Louis DN, Perry A, Reifenberger G, Deimling AV, Figarella-Branger D, Cavenee WK. et al. The 2016 world health organization classification of tumors of the central nervous system: A summary. Acta Neuropathol 2016; 131: 803-20
    CrossrefPubMedGoogle Scholar
  • 3 Yeom KW, Mobley BC, Lober RM, Andre JB, Partap S, Barnes PD. et al. Distinctive MRI features of pediatric medulloblastoma subtypes. Am J Roentgenol 2013; 200: 895-903
    CrossrefPubMedGoogle Scholar
  • 4 Perreault S, Ramaswamy V, Achrol AS, Chao K, Liu TT, Shih D. et al. MRI surrogates for molecular subgroups of medulloblastoma. Am J Neuroradiol 2014; 35: 1263-9
    CrossrefPubMedGoogle Scholar
  • 5 Meyers SP, Kemp SS, Tarr RW. MR Imaging features of medulloblastoma. Am J Roentgenol 1992; 158: 859-65
    CrossrefPubMedGoogle Scholar
  • 6 Northcott PA, Korshunov A, Witt H, Hielscher T, Eberhart CG, Mack S. et al. Medulloblastoma comprises four distinct molecular variants. J Clin Oncol 2011; 29: 1408-14
    CrossrefPubMedGoogle Scholar
  • 7 Robinson G. Impact of tumor location on medulloblastoma subtyping and treatment. Pediatr Blood Cancer 2013; 60: 1393-4
    CrossrefPubMedGoogle Scholar
  • 8 Vieira M, Melo D, Amaral G, Rodrigues MO, Concepción M, Otaduy GT. et al. Medulloblastoma: Correlation among findings of conventional magnetic resonance imaging, diffusion-weighted imaging and proton magnetic resonance spectroscopy. Radiol Bras Radiologia Brasileira 2008; 41: 373-8
    Google Scholar
  • 9 Ahmad T, Gohar M. MRI evaluation of medulloblastoma with histopahtological correlation. Biomedica 2014; 30: 1-5
    Google Scholar
  • 10 Huang PI, Lin SC, Lee YY, Ho DMT, Guo WY, Chang KP. et al. Large cell/anaplastic medulloblastoma is associated with poor prognosis—A retrospective analysis at a single institute. Childs Nerv Syst 2017; 33: 1285-94
    CrossrefPubMedGoogle Scholar
  • 11 Raleigh DR, Varenika V, Tihan T, Daphne A. Radiographic and molecular classification of medulloblastoma. JSM Clin Oncol Res 2014; 2: 1-10
    Google Scholar
  • 12 Rutkowski S, von Hoff K, Emser A, Zwiener I, Pietsch T, Figarella-Branger D. et al. Survival and prognostic factors of early childhood medulloblastoma: An international meta-analysis. J Clin Oncol 2010; 28: 4961-8
    CrossrefPubMedGoogle Scholar