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CC BY-NC-ND 4.0 · Indian J Radiol Imaging 2019; 29(03): 327-331
DOI: 10.4103/ijri.IJRI_148_19
Case Report

Adenocarcinoma and neuroendocrine tumor arising within presacral teratoma associated with Currarino syndrome: A case report

Shohei Chatani
Departments of Diagnostic and Interventional Radiology, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku Nagoya 464-8681, Japan
,
Hiroaki Onaya
Departments of Diagnostic and Interventional Radiology, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku Nagoya 464-8681, Japan
,
Seiichi Kato
Departments of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku Nagoya 464-8681, Japan
,
Yoshitaka Inaba
Departments of Diagnostic and Interventional Radiology, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku Nagoya 464-8681, Japan
› Author Affiliations Financial support and sponsorship Nil.
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Abstract

We present a case of a 59-year-old woman with a malignant tumor arising within presacral teratoma associated with Currarino syndrome (CS). A characteristic crescent-shaped sacrum was detected on preoperative image examination and the presacral mass was pathologically diagnosed as a malignant tumor associated with CS. To our knowledge, this is the first case report of presacral teratoma associated with CS coexisting with both adenocarcinoma and a neuroendocrine tumor.

Keywords

Adenocarcinoma - Currarino syndrome - neuroendocrine tumor - teratoma


Publication History

Received: 25 March 2019

Accepted: 11 September 2019

Article published online:
22 July 2021

© 2019. Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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  • References

  • 1 Currarino G, Coln D, Votteler T. Triad of anorectal, sacral, and presacral anomalies. Am J Radiol 1981; 137: 395-8
    Google Scholar
  • 2 Lynch SA, Wang Y, Strachan T, Burn J, Lindsay S. Autosomal dominant sacral agenesis: Surrarino syndrome. J Med Genet 2000; 37: 561-6
    CrossrefPubMedGoogle Scholar
  • 3 Emans PJ, Kootstra G, Marcelis CL, Beuls EA, van Heurn LW. The currarino triad: The variable expression. J Pediatr Surg 2005; 40: 1238-42
    CrossrefPubMedGoogle Scholar
  • 4 Martucciello G, Torre M, Belloni E, Lerone M, Pini Prato A, Cama A. et al. Currarino syndrome: Proposal of diagnostic and therapeutic protocol. J Pediatr Surg 2004; 39: 1305-11
    CrossrefPubMedGoogle Scholar
  • 5 Dirix M, van Becelaere T, Berkenbosch L, van Baren R, Wijnen RM, Wijnen MH. et al. Malignant transformation in sacrococcygeal teratoma and in presacral teratoma associated with currarino syndrome: A comparative study. J Pediatr Surg 2015; 50: 462-4
    CrossrefPubMedGoogle Scholar
  • 6 Ashcraft KW, Holder TM. Hereditary presacral teratoma. J Pediatr Surg 1974; 9: 691-7
    CrossrefPubMedGoogle Scholar
  • 7 Yates VD, Wilroy RS, Whitington GL, Simmons JC. Anterior sacral defects: An autosomal dominantly inherited condition. J Pediatr 1983; 102: 239-42
    CrossrefPubMedGoogle Scholar
  • 8 Norum J, Wist E, Bostad L. Incomplete currarino syndrome with a presacral leiomyosarcoma. Acta Oncol 1991; 30: 987-8
    CrossrefPubMedGoogle Scholar
  • 9 Urioste M, Garicai-Andrade M, del Carmen, Valle L, Robledo M, González-Palacios F. Malignant degeneration of presacral teratoma in the Currarion anomaly. Am J Med Genet Part A 2004; 128: 299-304
    CrossrefPubMedGoogle Scholar
  • 10 Pendlimari R, Leonard D, Dozois EJ. Rare malignant neuroendocrine transformation of presacral teratoma in patient with Currarino syndrome. Int J Colorectal Dis 2010; 24: 1383-4
    CrossrefPubMedGoogle Scholar
  • 11 Ciotti P, Mandich P, Bellone E, Ceppa P, Bovio M, Ameri P. et al. Currarino syndrome with pelvic neuroendocrine tumor diagnosed by post-mortem genetic analysis of tissue specimens. Am J Med Genet Part A 2011; 155: 2750-3
    CrossrefPubMedGoogle Scholar
  • 12 Baltogiannis N, Mavridis G, Soutis M, Keramidas D. Currarino triad associated with Hirschsprung’s disease. J Pediatr Surg 2003; 38: 1086-9
    CrossrefPubMedGoogle Scholar
  • 13 AbouZeid AA, Mohammad SA, Abolfotoh M, Radwan AB, Ismail MME, Hassan TA. The currarino triad: What pediatric surgeons need to know. J Pediatr Surg 2017; 52: 1260-8
    CrossrefPubMedGoogle Scholar
  • 14 Griffiths D, Wass J, Look K, Sutton G. Malignant degeneration of a mature cystic teratoma five decades after discovery. Gynecol Oncol 1995; 59: 427-9
    CrossrefPubMedGoogle Scholar
  • 15 Rose PG, Tak WK, Reale FR. Squamous cell carcinoma arising in a mature cystic teratoma with metastasis to the paraaortic nodes. Gynecol Oncol 1993; 50: 131-3
    CrossrefPubMedGoogle Scholar
  • 16 Curling OM, Potsides PN, Hundson CN. Malignant change in benign cystic teratoma of the ovary. Br J Obstet Gynecol 1979; 86: 399-402
    CrossrefPubMedGoogle Scholar
  • 17 Chandha S, Schaberg A. Malignant transformation in benign cystic teratomas: Dermoids of the ovary. Eur J Obstet Gynecol Repro Biol 1988; 29: 329-38
    CrossrefPubMedGoogle Scholar
  • 18 Kim SM, Choi HS, Byun JS, Kim YH, Kim KS, Rim SY. et al. Mucinous adenocarcinoma and stromal carcinoid tumor arising in one mature cystic teratoma of the ovary with synchronous cervical cancer. J Obstet Gynaecol Res 2003; 29: 28-32
    CrossrefPubMedGoogle Scholar
  • 19 Armah HB, Parwani AV, Perepletchikov AM. Synchronous primary carcinoid tumor and primary adenocarcinoma arising within mature cystic teratoma of horseshoe kidney: A unique case report and review of the literature. Diagn Pathol 2009; 4: 17
    CrossrefPubMedGoogle Scholar
  • 20 Hinshaw HD, Smith AL, Desouki MM, Olawaiye AB. Malignant transformation of a mature cystic ovarian teratoma into thyroid carcinoma, mucinous adenocarcinoma and stromal carcinoid: A case report and literature review. Case Rep Obstet Gynecol 2012; 2012: 269489
    PubMedGoogle Scholar
  • 21 Agarwal S, Mullick S, Gupta K, Dewan RK. Mediastinal teratoma with coexisting adenocarcinoma and carcinoid tumor (somatic-type malignancy): A case report with a review of the literature. Turk Thorac J 2015; 16: 101-4
    CrossrefPubMedGoogle Scholar
  • 22 Higgins A, Eisa W, Walton J, Baber J, Zhu S, Williams H. Metastatic mucinous adenocarcinoma and carcinoid tumor arising from a mature cystic teratoma of a horseshoe kidney. Urol Case Rep 2017; 11: 39-41
    CrossrefPubMedGoogle Scholar