Correlation of Hormone Receptor and Human Epidermal Growth Factor Receptor‑2/neu Expression in Breast Cancer with Various Clinicopathologic Factors

Cherry Bansal; Aarti Sharma; Mukta Pujani; Meenu Pujani; Kiran Sharma; A Srivastava; U Singh

doi:10.4103/ijmpo.ijmpo_98_16

Indian Journal of Medical and Paediatric Oncology, Table of Contents

CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2017; 38(04): 483-489
DOI: 10.4103/ijmpo.ijmpo_98_16

Original Article

Correlation of Hormone Receptor and Human Epidermal Growth Factor Receptor‑2/neu Expression in Breast Cancer with Various Clinicopathologic Factors

Cherry Bansal

Department of Pathology, Era's Medical College, Lucknow, Uttar Pradesh, India

,

Aarti Sharma

Department of Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India

,

Mukta Pujani

Department of Pathology, ESIC Medical College, Faridabad, Haryana, India

,

Meenu Pujani

Lab Medicine, Metro Heart Institute and Super Speciality Hospital, Faridabad, Haryana, India

,

Kiran Sharma

Department of Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India

,

A Srivastava

Department of Pathology, Era's Medical College and Hospital, Lucknow, Uttar Pradesh, India

,

U Singh

Department of Pathology, King George's Medical University, Lucknow, Uttar Pradesh, India

› Author Affiliations

Abstract

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Abstract

Background: A significant development in the breast carcinoma management is the correlation between the presence of hormone receptors in the tumor and response to hormonal therapy and chemotherapy. Human epidermal growth factor receptor-2/neu (Her-2/neu) overexpression also serves as a very useful parameter to predict response to herceptin. Aim of Study: The study was conducted to correlate immunohistochemical expression of markers such as estrogen receptor (ER), progesterone receptor (PR), and Her-2/neu with various clinicopathologic parameters. Materials and Methods: The study included 509 cases of breast carcinoma over a period of 5 years (from May 2009 to May 2014). Immunohistochemistry (IHC) for ER, PR, and her-2/neu was performed. Results: ER positivity was observed in 42.8% (218/509) cases, PR positivity in 31.8% (194/509) cases whereas her-2 neu positivity was seen in 40.7% (203/509) cases. Triple marker (ER, PR, and Her-2/neu) negative cases were 23.6% (120/509) cases. ER and PR expression was found to have a statistically significant correlation with tumor grade. Statistically significant correlation was observed between tumor size and tumor grade and her-2/neu expression. Her-2/neu expression showed statistically significant association with tumor stage. As the tumor grade increased, the proportion of triple-negative cases went on increasing, which was statistically significant. Conclusion: IHC has an increasingly important prognostic role in determination of factors that affect clinicopathologic features. Nevertheless, the results of this large series showed different patterns of findings with respect to clinicopathologic features.

Keywords

Breast cancer - estrogen receptor - human epidermal growth factor receptor-2/neu - hormone receptors - progesterone receptor

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References

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