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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2020; 41(03): 430-433
DOI: 10.4103/ijmpo.ijmpo_96_19
Practitioner Section

Anaplastic Multiple Myeloma- a Morphological Challenge – A Case Series

S Sakthisankari
Department of Pathology, PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, India
,
Prasanna N Kumar
Department of Pathology, PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, India
,
Tabbu Syed
Department of Pathology, PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, India
› Author Affiliations Financial support and sponsorship Nil.
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Abstract

Anaplastic multiple myeloma (AMM) is a rare and aggressive variant of plasma cell neoplasm. It is relatively treatment resistant when compared to conventional myeloma. It can arise de novo or transform from a preexisting plasma cell myeloma. Morphologically, AMM is recognized by the presence of immature plasma cells and pleomorphic, multilobated cells. Here, we present three cases of AMM.

Keywords

Anaplastic myeloma - anaplastic variant of multiple myeloma - bizarre plasma cells - multilobated plasma cells


Publication History

Received: 13 April 2019

Accepted: 03 January 2020

Article published online:
28 June 2021

© 2020. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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  • References

  • 1 Rodriguez C, Strowd RE, Grier DD. Anaplastic myeloma arising from myeloma: Successful management of two diseases in an individual. Blood 2017; 130: 5410
    Google Scholar
  • 2 Sethi S, Miller I. Plasma cell myeloma with anaplastic transformation. Blood 2016; 128: 2106
    CrossrefPubMedGoogle Scholar
  • 3 Harankhedkar S, Gupta R, Rahman K. Pleomorphic multinucleated plasma cells simulating megakaryocytes in an anaplastic variant of myeloma. Turk J Haematol 2018; 35: 150-1
    CrossrefPubMedGoogle Scholar
  • 4 Ammannagari N, Celotto K, Neppalli V, Lee K, Holstein SA. Anaplastic multiple myeloma: An aggressive variant with a poor response to novel therapies. Clin Lymphoma Myeloma Leuk 2016; 16: e129-31
    CrossrefPubMedGoogle Scholar
  • 5 Rao S, Kar R, Pati HP. Anaplastic myeloma: A morphologic diagnostic dilemma. Indian J Hematol Blood Transfus 2008; 24: 188-9
    CrossrefPubMedGoogle Scholar
  • 6 Fujimi A, Nagamachi Y, Yamauchi N, Kanisawa Y. Morphological transformation of myeloma cells into multilobated plasma cell nuclei within 7 days in a case of secondary plasma cell leukemia that finally transformed as anaplastic myeloma. Case Rep Hematol 2017; 2017: 5758368
    PubMedGoogle Scholar