Download PDF
CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2017; 38(04): 471-477
DOI: 10.4103/ijmpo.ijmpo_95_16
Original Article

A Profile of Pediatric Solid Tumors: A Single Institution Experience in Kashmir

Namita Sharma
Department of Medical Oncology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India
,
Ayesha Ahmad
Department of Paediatrics, Jawaharlal Nehru Medical College and Hospital, Aligarh Muslim University, Aligarh, Uttar Pradesh, India
,
Gull M Bhat
Department of Medical Oncology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India
,
Sheikh Aziz
Department of Medical Oncology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India
,
Mohammad Lone
Department of Radiation Oncology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India
,
Nisar Bhat
Department of Paediatric Surgery, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India
› Author Affiliations Financial support and sponsorship Nil.
› Further Information
  PDF Download Permissions and Reprints

Abstract

Aims: The purpose of this retroprospective study was to study the epidemiological characteristics and outcomes of children with solid tumors at our institution. Subjects and Methods: Three hundred and three pediatrics patients registered at Regional Cancer Centre (RCC), Sher-i-Kashmir Institute of Medical Sciences (SKIMS), Srinagar, Kashmir, between January 2008 and June 2014, were analyzed with regard to demographic status, presentingcomplaints, investigations, treatment, morbidity, and outcomes. Standard statistical methods were used for analysis. Results: Among 19,880 patients registered at RCC, SKIMS from January 2008 till June 2014, 986 (4.9%) were of pediatric age group. Of these, 303 (30.7%) patients had pediatric solid tumors. The male-to-female ratio was 1.04, there were no infants (up to 27 days), 6% were infants and toddlers (28 days–23 months), 39% were children (2–11 years), and 55% were adolescents (12–19 years). There were 86% rural patients and 14% urban patients. Mostcommon were central nervous system tumors (25.74%), followed by germ cell tumors (14.52%), primitive neuroectodermal tumor/Ewing sarcoma (13.86%), Wilms' tumor (8.9%), osteosarcoma (6.6%), rhabdomyosarcoma (5.6%), colorectal cancer (5.28%), neuroblastoma (4.9%), and retinoblastoma (2.6%). Outcomes: 33.9% patients went into remission, 35.64% were defaulters, 2.97% had stable disease, 2.31% had partial response, 20.79% expired, and 3.96% were still on treatment. Of all these patients, 5.28% had a relapse. Conclusions: Across the series, advanced stage of presentation, a high incidence of default and poor follow-up was seen. Multiple interrelated factors are responsible for the poorer outlook of childhood cancer in Kashmir.

Keywords

Epidemiologic profile - outcomes of treatment - pediatric solid tumors


Publication History

Article published online:
04 July 2021

© 2017. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used forcommercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 

  • References

  • 1 Barr R, Riberio R, Agarwal B, Masera G, Hesseling P, Magrath I. Pediatric oncology in countries with limited resources. In: Pizzo PA, Poplack DG, editors. Principles and Practice of Pediatric Oncology. 5th ed. Philadelphia: Lippincott Williams and Wilkins; 2006. p. 1605-17.
  • 2 Ries LA, Smith MA, Gurney JG, Linet M, Tamra T, Young JL, et al., editors. Cancer Incidence and Survival among Children and Adolescents: United States SEER Program 1975-1995, National Cancer Institute, SEER Program. NIH Pub. No. 99-4649. Bethesda, MD, 1999.
  • 3 Kroll ME, Stiller CA. Time Trends in Incidence 1966-2000. Childhood Cancers in Britain: Incidence, Survival, Mortality. Oxford Scholarship Online; 2009.
  • 4 Harif M, Barsaoui S, Benchekroun S, Bouhas R, Doumbé P, Khattab M, et al. Treatment of B-cell lymphoma with LMB modified protocols in Africa – Report of the French-African Pediatric Oncology Group (GFAOP). Pediatr Blood Cancer 2008;50:1138-42.
  • 5 Howard SC, Pedrosa M, Lins M, Pedrosa A, Pui CH, Ribeiro RC, et al. Establishment of a pediatric oncology program and outcomes of childhood acute lymphoblastic leukemia in a resource-poor area. JAMA 2004;291:2471-5.
  • 6 Qaddoumi I, Musharbash A, Elayyan M, Mansour A, Al-Hussaini M, Drake J, et al. Closing the survival gap: Implementation of medulloblastoma protocols in a low-income country through a twinning program. Int J Cancer 2008;122:1203-6.
  • 7 Rivera GK, Quintana J, Villarroel M, Santana VM, Rodriguez-Galindo C, Neel MD, et al. Transfer ofcomplex frontline anticancer therapy to a developing country: The St. Jude osteosarcoma experience in Chile. Pediatr Blood Cancer 2008;50:1143-6.
  • 8 Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ. Cancer statistics, 2009. CA Cancer J Clin 2009;59:225-49.
  • 9 Bleyer A, O'Leary M, Barr R, Ries LA, editors. Cancer Epidemiology in Older Adolescents and Young Adults 15 to 29 Years of Age, Including SEER Incidence and Survival: 1975-2000. NIH Publication. No. 06-5767. Bethesda, MD: National Cancer Institute; 2006.
  • 10 Crist WM, Anderson JR, Meza JL, Fryer C, Raney RB, Ruymann FB, et al. Intergroup rhabdomyosarcoma study-IV: Results for patients with nonmetastatic disease. J Clin Oncol 2001;19:3091-102.
  • 11 Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, et al., editors. SEER Cancer Statistics Review, 1975-2011. Bethesda, MD: National Cancer Institute. Based on November 2013 SEER Data Submission, Posted to the SEER. Available from: http://www.seer.cancer.gov/csr/1975_2011/. [Last accessed on 2014 Apr 12].
  • 12 Rathi AK, Kumar S, Ashu A, Singh K, Bahadur A. Epidemiology of pediatric tumors at a tertiary care centre. Indian J Med Paediatr Oncol 2007;28:33-5.
  • 13 Kusumakumary P, Jacob R, Jothirmayi R, Nair MK. Profile of pediatric malignancies: A ten year study. Indian Pediatr 2000;37:1234-8.
  • 14 Summary-Report on Causes of Death: 2001-2003 in India. Available from: http://www.censusindia.gov.in/Vital_Statistics/Summary_Report_Death_01_03.pdf. [Last accessed on 2013 Sep 24].
  • 15 Three Year Report of the Population Based Cancer Registries 2009-2011: Report of 25 PBCRs; National Cancer Registry Programme, Indian Council Medical Research, Bangalore; 2013. Available from: http://www.ncrpindia.org/Reports/PBCR_2009_2011.aspx. [Last accessed on 2013 Sep 24].
  • 16 Satyanarayana L, Asthana S, Labani SP. Childhood cancer incidence in India: A review of population-based cancer registries. Indian Pediatr 2014;51:218-20.
  • 17 Kellie SJ, Howard SC. Global child health priorities: What role for paediatric oncologists? Eur J Cancer 2008;44:2388-96.
  • 18 Howard SC, Marinoni M, Castillo L, Bonilla M, Tognoni G, Luna-Fineman S, et al. Improving outcomes for children with cancer in low-income countries in Latin America: A report on the recent meetings of the Monza International School of Pediatric Hematology/Oncology (MISPHO)-Part I. Pediatr Blood Cancer 2007;48:364-9.
  • 19 Gurney JG, Bondy ML. Epidemiology of childhood cancer. In: Pizzo PA, Poplack DG, editors. Principles and Practice of Paediatric Oncology. 5th ed. Philadelphia: Lippincott Williams and Wilkins; 2006. p. 2-14.
  • 20 Arora B, Kurkure P, Parikh P. Childhood cancers: Perspectives in India. J Indian Med Assoc 2005;103:479-82.
  • 21 Sahu S, Banavali SD, Pai SK, Nair CN, Kurkure PA, Motwani SA, et al. Retinoblastoma: Problems and perspectives from India. Pediatr Hematol Oncol 1998;15:501-8.
  • 22 Nair R, Pai SK, Saikia TK, Nair CN, Kurkure PA, Gopal R, et al. Malignant germ cell tumors in childhood. J Surg Oncol 1994;56:186-90.
  • 23 Shah A. Pattern of pediatric solid malignant tumors in Kashmir. Indian Pediatr 1992;29:1045-6.
  • 24 Aziz AS, Shah AH, Sheikh KA. Clinical profile of abdominal tumours in children in Kashmir. 1986. Available from: http://medind.nic.in/haa/t02/i1/haat02i1p25g.pdf. [Last accessed on 2014 Apr 17].
  • 25 Khan PS, Akhter Z, Majeed S, Wani MY, Hayat H. Clinicopathological Profile of Childhood Primary Abdominal Tumours in Kashmir. Indian J Surg 2015;77 Suppl 2:361-4.