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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2017; 38(03): 349-353
DOI: 10.4103/ijmpo.ijmpo_84_16
Review Article

Round Cell Tumors: Classification and Immunohistochemistry

Shweta Sharma
Department of Conservative Dentistry and Endodontics, Eklavya Dental College and Hospital, Kotputli, Rajasthan, India
,
R Kamala
Department of Oral Medicine and Radiology, ESIC PGIMSR Medical College and Hospital, Bengaluru, Karnataka, India
,
Divya Nair
PDM Dental College and Research Institute, Bahadurgarh, Haryana, India
,
Raju Ragavendra T
Oral Pathology Division Oral Basic Clinical Sciences, College of Dentistry, Qassim Private Colleges, Buraidah 51411, India
,
Swapnil Mhatre
Department of Pedodontics, RR Dental College, Udaipur, Rajasthan, India
,
Robin Sabharwal
BRS Dental College and Hospital, Sultanpur, Haryana, India
,
Basanta Choudhury
Department of Oral Medicine and Radiology, Institute of Dental Sciences and Sum Hospital, Bhubaneswar, Odisha, India
,
Vivek Rana
Private Practioner, Lajpat Nagar, New Delhi, India
› Author Affiliations Financial support and sponsorship Nil.
› Further Information
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Abstract

Round cell tumors as the name suggest are comprised round cells with increased nuclear-cytoplasmic ratio. This group of tumor includes entities such as peripheral neuroectodermal tumor, rhabdomyosarcoma, synovial sarcoma, non-Hodgkin's lymphoma, neuroblastoma, hepatoblastoma, Wilms' tumor, and desmoplastic small round cell tumor. These round cells tumors are characterized by typical histological pattern, immunohistochemical, and electron microscopic features that can help in differential diagnosis. The present article describes the classification and explains the histopathology and immunohistochemistry of some important round cell tumors.

Keywords

Ewing sarcoma - lymphoma - round cell tumor


Publication History

Article published online:
04 July 2021

© 2017. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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  • References

  • 1 Devoe K, Weidner N. Immunohistochemistry of small round-cell tumors. Semin Diagn Pathol 2000;17:216-24.
  • 2 Rajwanshi A, Srinivas R, Upasana G. Malignant small round cell tumors. J Cytol 2009;26:1-10.
  • 3 Akhtar M, Ali MA, Sabbah R, Bakry M, Nash JE. Fine-needle aspiration biopsy diagnosis of round cell malignant tumors of childhood. A combined light and electron microscopic approach. Cancer 1985;55:1805-17.
  • 4 McGahey BE, Moriarty AT, Nelson WA, Hull MT. Fine-needle aspiration biopsy of small round blue cell tumors of childhood. Cancer 1992;69:1067-73.
  • 5 Layfield LJ, Liu K, Dodge RK. Logistic regression analysis of small round cell neoplasms: A cytologic study. Diagn Cytopathol 1999;20:271-7.
  • 6 Rajendran A, Sivapathasundharam B. Shafer's Textbook of Oral Pathology. 7th ed. New Delhi: Elsevier; 2012.
  • 7 Das D, Kuri GC, Deka P, Bhattacharjee K, Bhattacharjee H, Deka AC. Primary primitive neuroectodermal tumor of the orbit. Indian J Ophthalmol 2009;57:391-3.
  • 8 Silverman JF, Berns LA, Holbrook CT, Neill JS, Joshi VV. Fine needle aspiration cytology of primitive neuroectodermal tumors. A report of these cases. Acta Cytol 1992;36:541-50.
  • 9 Goldblum JR, Weiss SW. Enzinger and Weiss's Soft Tissue Tumors. 4th ed. Canada: Mosby; 2001.
  • 10 Wenig BM. Atlas of Head and Neck Pathology. 3rd ed. Philadelphia: Elsevier; 2015.
  • 11 Odoi AT, Dassah ET, Darkey DE, Owusu-Afriyie O, Valkov AY. Advanced alveolar rhabdomyosarcoma of the uterus: A case report. Afr J Reprod Health 2009;13:167-73.
  • 12 Chang F. Desmoplastic small round cell tumors: Cytologic, histologic, and immunohistochemical features. Arch Pathol Lab Med 2006;130:728-32.
  • 13 Hayes-Jordan A, Anderson PM. The diagnosis and management of desmoplastic small round cell tumor: A review. Curr Opin Oncol 2011;23:385-9.
  • 14 Akhtar M, Iqbal MA, Mourad W, Ali MA. Fine-needle aspiration biopsy diagnosis of small round cell tumors of childhood: A comprehensive approach. Diagn Cytopathol 1999;21:81-91.
  • 15 Barnoud R, Sabourin JC, Pasquier D, Ranchère D, Bailly C, Terrier-Lacombe MJ, et al. Immunohistochemical expression of WT1 by desmoplastic small round cell tumor: A comparative study with other small round cell tumors. Am J Surg Pathol 2000;24:830-6.
  • 16 Mostofi FK, Davis CJ Jr. Histological Typing of Kidney Tumours: In Collaboration with L. H. Sobin and Pathologist in 6 countries. Springer Berlin Heidelberg; 1998.
  • 17 Subramaniam MM, Lazar N, Navarro S, Perbal B, Llombart-Bosch A. Expression of CCN3 protein in human Wilms' tumors: Immunohistochemical detection of CCN3 variants using domain-specific antibodies. Virchows Arch 2008;452:33-9.
  • 18 Sullivan LM, Atkins KA, LeGallo RD. PAX immunoreactivity identifies alveolar rhabdomyosarcoma. Am J Surg Pathol 2009;33:775-80.