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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2017; 38(03): 374-376
DOI: 10.4103/ijmpo.ijmpo_7_17
Case Report

Metaplastic Carcinoma of Breast and Neurofibromatosis 1: A Rare Association

Gnanapriya Vellaisamy
Department of Pathology, St. John's Medical College, Bengaluru, Karnataka, India
,
Suravi Mohanty
Department of Pathology, St. John's Medical College, Bengaluru, Karnataka, India
,
Pritilata Rout
Department of Pathology, St. John's Medical College, Bengaluru, Karnataka, India
,
Suraj Manjunath
Department of Surgical Oncology, St. John's Medical College, Bengaluru, Karnataka, India
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Abstract

Neurofibromatosis 1 (NF1) patients are generally at higher risk of developing common malignant tumors such as brain and soft tissue tumors. These patients are 5-fold increased the risk of developing breast cancer by the age of 50 years after that the risk remains the same. The most common reported cancer is infiltrating duct carcinoma. We report a case of 61-year-old female with NF1 presented with pain and breast lump for the past 2 months. On mammography, a retroareolar solid cystic lesion measuring 32 mm × 30 mm × 30 mm was noted which was definitive for malignancy. Right-modified radical mastectomy with axillary lymph node dissection was done which revealed a neoplasm composed of glandular and squamous components. Immunohistochemically, these cells were triple negative for estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2-neu and expressed markers of basal cell differentiation. The final pathological staging was T2N0M0. This is the fourth case report in the English literature with such association. In this case report, we discussed the importance of breast cancer screening in such patients along with a review of the literature.

Keywords

Breast screening - metaplastic - neurofibromatosis


Publication History

Article published online:
04 July 2021

© 2017. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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