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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2019; 40(03): 391-395
DOI: 10.4103/ijmpo.ijmpo_74_18
Original Article

Pattern of T-cell Non-Hodgkin's Lymphoma in a Tertiary Care Center in North East India

Debanwita Mahanta
Department of Pathology, Dr. B. Borooah Cancer Institute, Guwahati, Assam, India
,
Jagannath Dev Sharma
Department of Pathology, Dr. B. Borooah Cancer Institute, Guwahati, Assam, India
,
Anupam Sarma
Department of Pathology, Dr. B. Borooah Cancer Institute, Guwahati, Assam, India
,
Lopamudra Kakoti
Department of Pathology, Dr. B. Borooah Cancer Institute, Guwahati, Assam, India
,
Amal Chandra Kataki
Department of Gynaecologic Oncology, Dr. B. Borooah Cancer Institute, Guwahati, Assam, India
,
Shiraj Ahmed
Department of Pathology, Dr. B. Borooah Cancer Institute, Guwahati, Assam, India
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Abstract

Context: The non-Hodgkin's lymphomas (NHLs) are lymphoid neoplasms that arise primarily in the lymph nodes. They are classified into B-cell, T-cell, and natural killer cell types and are subtyped on the basis of morphologic and immunohistochemical studies. T-cell neoplasms are clonal tumors of mature and immature T-cells at various stages of differentiation. T-cell lymphoma is common in Asia compared to Europe and America. The pattern and prevalence of T-cell lymphoma in India are, however, different from that of other Asian countries. Aims: The main aim of this study is to analyze the prevalence and pattern of T-cell NHL in North East India, as less number of studies have been carried out in this part of the country. Settings and Design: A 5-year retrospective study (2012–2016) was carried out in our institute, which is a regional cancer center located in North East India. Materials and Methods: Five-year records of previously diagnosed cases were obtained, and then the hematoxylin- and eosin-stained sections and the immunohistochemistry slides were reviewed and studied. Results: A total number of 294 cases of NHL were reviewed in the study period. Seventy-one cases were found to be of T-cell NHL type which comprised 24% of the total NHL. Peripheral T-cell lymphoma not-otherwise specified (PTCL-NOS) (62%) was the most common followed by anaplastic large cell lymphoma (27%). T-lymphoblastic lymphoma (7%) was common in children and young adults. Conclusion: PTCL-(NOS) was found to be the most common T-cell lymphoma. Treatment of most of the cases was by chemotherapy using the cyclophosphamide, doxorubicin, vincristine, and prednisone regimen.

Keywords

Immunohistochemistry - North East India - peripheral T-cell lymphoma - T-cell non-Hodgkin lymphoma


Publication History

Received: 03 April 2018

Accepted: 21 June 2018

Article published online:
03 June 2021

© 2019. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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