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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2020; 41(03): 423-426
DOI: 10.4103/ijmpo.ijmpo_71_19
Practitioner Section

Ectopic Non-gestational Pure Choriocarcinoma of the Urinary Bladder in a Young Nulliparous Female: A Diagnostic Challenge

Rahul Mannan
Department of Pathology, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, Punjab
,
Sonam Sharma
Department of Pathology, Kalpana Chawla Government Medical College, Karnal, Haryana
,
Saloni Goyal
Department of Pathology, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, Punjab
,
Tejinder Singh Bhasin
Department of Pathology, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, Punjab
› Author Affiliations Financial support and sponsorship Nil.
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Abstract

Choriocarcinoma can occur at ectopic extragenital locations such as lungs, mediastinum, retroperitoneum, and even in the brain (nongestational choriocarcinoma). Choriocarcinoma arising in the urinary bladder is extremely uncommon with only a few cases reported worldwide. It is important to recognize and give comprehensive diagnosis of this entity, as it has poorer prognosis as compared to the conventional gestational choriocarcinoma and requires stepped-up chemotherapy. Here, we present such a case in a 19-year-old girl and the diagnostic conundrum associated with it.

Keywords

Choriocarcinoma - GATA-3 - nongestational - primary - urinary bladder


Publication History

Received: 09 March 2019

Accepted: 06 February 2020

Article published online:
28 June 2021

© 2020. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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  • References

  • 1 Cho JH, Yu E, Kim KH, Lee I. Primary choriocarcinoma of the urinary bladder – A case report. J Korean Med Sci 1992; 7: 369-72
    CrossrefPubMedGoogle Scholar
  • 2 Pradjatmo H. Choriocarcionoma in an infantile patient. Gen Med (Los Angel) 2016; 3: 217
    Google Scholar
  • 3 Patel D, Patel H, Patel P. et al. Choriocarcinoma - A rare tumour in a 15 year female. Int J Adv Case Rep 2015; 2: 1064-6
    Google Scholar
  • 4 Sharma S, Singh M, Bhuyan G, Mandal AK. Extragonadal dysgerminoma presenting as neck metastasis and masquerading as thyroid swelling. Clin Cancer Investig J 2016; 5: 43-5
    Google Scholar
  • 5 Sharma S, Dawson L, Mandal AK. Primary retroperitoneal teratoma with predominant neurogenic elements masquerading as adrenal tumor. Turk Patoloji Derg 2019; 35: 69-73
    PubMedGoogle Scholar
  • 6 Jindrak K, Bochetto JF, Alpert LI. Primary gastric choriocarcinoma: Case report with review of world literature. Hum Pathol 1976; 7: 595-604
    CrossrefPubMedGoogle Scholar
  • 7 Fine G, Smith RWJr, Pachter MR. Primary extragenital choriocarcinoma in the male subject. Case report and review of the literature. Am J Med 1962; 32: 776-94
    CrossrefPubMedGoogle Scholar
  • 1 Minei S, Matsui T, Obinata D, Yamaguchi K, Hirano D, Takahashi S, Sarin YK. Primary choriocarcinoma of the urinary bladder. Hinyokika Kiyo 2008; 54: 293-6
    CrossrefPubMedGoogle Scholar
  • 9 Mirkovic J, Elias K, Drapkin R, Barletta JA, Quade B, Hirsch MS. GATA3 expression in gestational trophoblastic tissues and tumours. Histopathology 2015; 67: 636-44
    CrossrefPubMedGoogle Scholar
  • 10 Banet N, Gown AM, Shih IeM, Kay LiQ, Roden RB, Nucci MR. et al GATA-3 expression in trophoblastic tissues: An immunohistochemical study of 445 cases, including diagnostic utility. Am J Surg Pathol 2015; 39: 101-8
    CrossrefPubMedGoogle Scholar
  • 11 Schneider DT, Calaminus G, Gobel U. Diagnostic value of alpha1-fetoprotein and beta-human chorionic gonadotropin in infancy and childhood. Pediatric Hematol and Oncol 2011; 18: 11-26
    CrossrefPubMedGoogle Scholar
  • 12 Matei D, Brown J, Frazier L. Updates in the management of ovarian germ cell tumors. Am Soc Clin Oncol Educ Book 2013; p: 210-216
    CrossrefPubMedGoogle Scholar