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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2018; 39(02): 153-158
DOI: 10.4103/ijmpo.ijmpo_70_17
Original Article

Pediatric Differentiated Thyroid Carcinoma Risk Factor For Analysis For Disease Free Survival

Yohana Azhar
Department of Surgery, Hasan Sadikin Hospital, Universitas Padjadjaran Bandung, West Java, Indonesia
,
Dimyati Achmad
Department of Surgery, Hasan Sadikin Hospital, Universitas Padjadjaran Bandung, West Java, Indonesia
,
Kiki Lukman
Department of Surgery, Hasan Sadikin Hospital, Universitas Padjadjaran Bandung, West Java, Indonesia
,
Dani Hilmanto
Department of Pediatrics, Hasan Sadikin Hospital, Universitas Padjadjaran Bandung, West Java, Indonesia
› Author Affiliations Financial support and sponsorship Nil.
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Abstract

Context:The context of this study was epidemiology pediatric thyroid cancer in Bandung, Indonesia. Aims: The aim of this study is to evaluate clinical characteristics and outcome between children and young adult patients with differentiated thyroid cancer (DTC) treated in our hospital. Settings and Design:This was a cohort retrospective study. Materials and Methods: The medical records of 144 patients with DTC who underwent thyroid surgery followed by radioiodine and thyroid hormone suppression were retrospectively reviewed. Thyroid cancers were diagnosed between January 2007 and December 2010. Participants consisted of 43 patients who were younger than 21 years old and 101 young adult patients (older than 21 years old but younger or equal to 40 years). The clinical characteristics and outcomes were analyzed and compared, and then, recurrence-free survival was evaluated using Kaplan–Meier methods. Statistical Analysis Used: Software R 3.3.0 version for Windows was used in this study. Results: Female has higher tendency to have thyroid cancer than male (P = 0.006). Based on histopathology report, classic papillary thyroid cancer is the most common cancer type in children than young adult. However, there was no significant difference between two groups regarding thyroid cancer size and multifocality (P = 0.815 and P = 0.370). The risk of recurrent ratio of children to young adults is 3.88 (95% confidence interval [CI] 1.38; 10.91). A similar result trend has been shown for sex type, histopathology type, number of nodules, surgical technique, and metastasis parameters (adjusted hazard ratio = 7.91, 95% CI 2.11; 29.67). Conclusions: DTC in children shows more aggressive behavior compared to young adult patients.

Keywords

Differentiated thyroid cancer - pediatrics - recurrence-free survival


Publication History

Article published online:
23 June 2021

© 2018. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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  • References

  • 1 Boltz MM, Enomoto L, Ornstein R, Saunders B, Hollenbeak C. Incidence and survival differences of differentiated thyroid cancer among younger women. Clin Oncol Adolesc Young Adults 2013; 3: 79-88
    Google Scholar
  • 2 La Vecchia C, Malvezzi M, Bosetti C, Garavello W, Bertuccio P. et al. Thyroid cancer mortality and incidence: A global overview. Int J Cancer 2015; 136: 2187-95
    CrossrefPubMedGoogle Scholar
  • 3 Chaukar DA, Vaidya AD. Pediatric thyroid cancers: An Indian perspective Indian J Surg Oncol 2012; 3: 166-72
    CrossrefPubMed
  • 4 Hung W, Sarlis NJ. Current controversies in the management of pediatric patients with well-differentiated nonmedullary thyroid cancer: A review. Thyroid 2002; 12: 683-702
    CrossrefPubMedGoogle Scholar
  • 5 Francis GL, Waguespack SG, Bauer AJ, Angelos P, Benvenga S. et al. Management guidelines for children with thyroid nodules and differentiated thyroid cancer. Thyroid 2015; 25: 716-59
    CrossrefPubMedGoogle Scholar
  • 6 Cordioli MI, Moraes L, Cury AN, Cerutti JM. Are we really at the dawn of understanding sporadic pediatric thyroid carcinoma?. Endocr Relat Cancer 2015; 22: R311-24
    CrossrefPubMedGoogle Scholar
  • 7 Khozeimeh N, Gingalewski C. Thyroid nodules in children: A single institution's experience.J. Oncol.2011;2011: 974125. Published online 2011 Oct 6.doi: 10.1155/2011/974125
  • 8 Lee YA, Jung HW, Kim HY, Choi H, Kim HY, Hah JH. et al. Pediatric patients with multifocal papillary thyroid cancer have higher recurrence rates than adult patients: A retrospective analysis of a large pediatric thyroid cancer cohort over 33 years. J Clin Endocrinol Metab 2015; 100: 1619-29
    CrossrefPubMedGoogle Scholar
  • 9 Wada N, Sugino K, Mimura T, Nagahama M, Kitagawa W, Shibuya H. et al. Pediatric differentiated thyroid carcinoma in stage I: Risk factor analysis for disease free survival. 2009; 9: 306
    PubMedGoogle Scholar
  • 10 Chen Q, Zou XH, Wei T, Huang QS, Sun YH. Prediction of ipsilateral and contralateral central lymph node metastasis in unilateral papillary thyroid carcinoma: A retrospective study. Gland Surg 2015; 4: 288-94
    PubMedGoogle Scholar
  • 11 Conzo G, Docimo G, Pasquali D, Mauriello C, Gambardella C, Esposito D. et al. Predictive value of nodal metastases on local recurrence in the management of differentiated thyroid cancer. Retrospective clinical study. BMC Surg 2013; 13 Suppl2: S3
    CrossrefPubMedGoogle Scholar
  • 12 Nixon IJ, Ganly I, Patel SG, Morris LG, Palmer FL, Thomas D. Observation of clinically negative central compartment lymph nodes in papillary thyroid carcinoma. Surgery 2013; 154: 1166-72
    CrossrefPubMedGoogle Scholar
  • 13 Barczyński M, Konturek A, Stopa M, Nowak W. Prophylactic central neck dissection for papillary thyroid cancer. Br J Surg 2013; 100: 410-8
    CrossrefPubMedGoogle Scholar
  • 14 Giordano D, Valcavi R, Thompson GB, Pedroni C, Renna L, Gradoni P. et al. Complications of central neck dissection in patients with papillary thyroid carcinoma: Results of a study on 1087 patients and review of the literature. Thyroid 2012; 22: 911-7
    CrossrefPubMedGoogle Scholar
  • 15 Chisholm EJ, Kulinskaya E, Tolley NS. Systematic review and meta-analysis of the adverse effects of thyroidectomy combined with central neck dissection as compared with thyroidectomy alone Laryngoscope 2009; 119: 1135-9
    CrossrefPubMed
  • 16 Givens DJ, Buchmann LO, Agarwal AM, Grimmer JF, Hunt JP. BRAF V600E does not predict aggressive features of pediatric papillary thyroid carcinoma Laryngoscope 2014; 124: E389-93
    CrossrefPubMed
  • 17 Fenton CL, Lukes Y, Nicholson D, Dinauer CA, Francis GL, Tuttle RM. The ret/PTC mutations are common in sporadic papillary thyroid carcinoma of children and young adults. J Clin Endocrinol Metab 2000; 85: 1170-5
    PubMedGoogle Scholar
  • 18 Chapnick DA, Warner L, Bernet J, Rao T, Liu X. Partners in crime: The TGFß and MAPK pathways in cancer progression Cell Biosci 2011; 1: 42
    CrossrefPubMed
  • 19 Buehler D, Hardin H, Shan W, Montemayor-Garcia C, Rush PS, Asioli S. et al. Expression of epithelial-mesenchymal transition regulators SNAI2 and TWIST1 in thyroid carcinomas. Mod Pathol 2013; 26: 54-61
    CrossrefPubMedGoogle Scholar
  • 20 Hardin H, Montemayor-Garcia C, Lloyd RV. et al. Thyroid cancer stem-like cells and epithelial-mesenchymal transition in thyroid cancers. Hum Pathol 2013; 44: 1707-13
    CrossrefPubMedGoogle Scholar