Download PDF
CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2017; 38(03): 306-310
DOI: 10.4103/ijmpo.ijmpo_67_16
Original Article

Status of Serum and Salivary Ascorbic Acid in Oral Potentially Malignant Disorders and Oral Cancer

Supriya Bhat
Department of Oral Medicine and Radiology, A. B. Shetty Memorial Institute of Dental Sciences, Nitte University, Mangalore, Karnataka, India
,
Subhas Gogineni Babu
Department of Oral Medicine and Radiology, A. B. Shetty Memorial Institute of Dental Sciences, Nitte University, Mangalore, Karnataka, India
,
Saidath K Bhat
Department of Orthodontics, A. B. Shetty Memorial Institute of Dental Sciences, Nitte University, Mangalore, Karnataka, India
,
Renita Lorina Castelino
Department of Oral Medicine and Radiology, A. B. Shetty Memorial Institute of Dental Sciences, Nitte University, Mangalore, Karnataka, India
,
Kumuda Rao
Department of Oral Medicine and Radiology, A. B. Shetty Memorial Institute of Dental Sciences, Nitte University, Mangalore, Karnataka, India
,
Medhini Madi
Department of Oral Medicine and Radiology, A. B. Shetty Memorial Institute of Dental Sciences, Nitte University, Mangalore, Karnataka, India
› Author Affiliations Financial support and sponsorship Nil.
› Further Information
  PDF Download Permissions and Reprints

Abstract

Background and Aims: The aim of this study was to estimate the detoxification status of serum and saliva by assessing the serum and salivary Vitamin C in oral potentially malignant disorders and oral cancer. Subjects and Methods: A total of 90 subjects, 30 subjects with oral potentially malignant disorders, 30 subjects with oral cancer, and 30 healthy subjects (controls) were included in the study. Serum and saliva were collected and levels of Vitamin C were assessed. Data obtained was analyzed using ANOVA test for the comparison between the groups. Post hoc Tukey's analysis was used for the comparison of the two study groups to the control group. Correlation between the groups was done using Pearson's correlation coefficient test. Results: The mean serum and salivary Vitamin C levels were decreased significantly in potentially malignant disorders and oral cancer when compared to healthy subjects. Conclusions: As significant reduction of Vitamin C is seen in saliva, it can be stated that saliva can be used as a reliable, noninvasive biomarker in diagnosis and management of potentially malignant disorders and oral cancer.

Keywords

Ascorbic acid - leukoplakia - oral cancer - oral submucous fibrosis - saliva - serum


Publication History

Article published online:
04 July 2021

© 2017. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 

  • References

  • 1 Gupta A, Bhatt ML, Misra MK. Lipid peroxidation and antioxidant status in head and neck squamous cell carcinoma patients. Oxid Med Cell Longev 2009;2:68-72.
  • 2 Rai B. Salivary levels Vitamin C and E in different histological grading of oral cancer. Pesqui Bras Odontopediatria Clín Integr 2008;8:123-5.
  • 3 Barikbin B, Yousefi M, Rahimi H, Hedayati M, Razavi SM, Lotfi S. Antioxidant status in patients with lichen planus. Clin Exp Dermatol 2011;36:851-4.
  • 4 Mireskandari L, Ziai SA, Salehian P, Noormohammadi I, Mahmoudian M. Serum ascorbic acid, Vitamin A and beta carotene levels in Iranian patients with cancer. Arch Iran Med 1999;9:145-7.
  • 5 Rai B, Kharb S, Jain R, Anand SC. Salivary Vitamin E and C in lichen planus. Gomal J Med Sci 2008;6(2):91-92.
  • 6 Castelli A, Martorana GE, Frasca AM, Meucci E. Colorimetric determination of plasma Vitamin C: Comparison between 2,4-dinitrophenylhydrazine and phosphotungstic acid methods (author's transl)]. Acta Vitaminol Enzymol 1981;3:103-10.
  • 7 Kayden HJ, Chow CK, Bjornson LK. Spectrophotometric method for determination of tocopherol in red blood cells. J Lipid Res 1973;14:533-40.
  • 8 Borek C. Antioxidants and cancer. Sci Med (Phila) 1997;4:51-62.
  • 9 Niki E, Noguchi N, Tsuchihashi H, Gotoh N. Interaction among Vitamin C, Vitamin E, and beta-carotene. Am J Clin Nutr 1995;62 6 Suppl: 1322S-6S.
  • 10 Lawal AO, Kolude B, Adeyemi BF, Lawoyin JO, Akang EE. Serum antioxidant vitamins and the risk of oral cancer in patients seen at a tertiary institution in Nigeria. Niger J Clin Pract 2012;15:30-3.
  • 11 Shetty SR, Babu S, Kumari S, Shetty P, Vijay R, Karikal A. Evaluation of micronutrient status in serum and saliva of oral submucous fibrosis patients: A clinicopathological study. Indian J Med Paediatr Oncol 2012;33:224-6.
  • 12 Anuradha CD, Devi CS. Serum protein, ascorbic acid & iron & tissue collagen in oral submucous fibrosis – A preliminary study. Indian J Med Res 1993;98:147-51.
  • 13 Tuovinen V, Väänänen M, Kullaa A, Karinpää A, Markkanen H, Kumpusalo E. Oral mucosal changes related to plasma ascorbic acid levels. Proc Finn Dent Soc 1992;88:117-22.
  • 14 Barikbin B, Yousefi M, Rahimi H, Hedayati M, Razavi SM, Lotfi S. Antioxidant status in patients with lichen planus. Clin Exp Dermatol 2011;36:851-4.
  • 15 Marakala V, Malathi M, Shivashankara AR. Lipid peroxidation and antioxidant vitamin status in oral cavity and oropharyngeal cancer patients. Asian Pac J Cancer Prev 2012;13:5763-5.
  • 16 Gupta A, Bhatt ML, Misra MK. Lipid peroxidation and antioxidant status in head and neck squamous cell carcinoma patients. Oxid Med Cell Longev 2009;2:68-72.
  • 17 Hegde N, Suchetha NK, Hegde MN, Chandra MP, Nireeksha. Lipid peroxidation and Vitamin C levels in saliva of oral precancerous patients - An in-vitro study. Res J Pharm Biol Chem Sci 2011;2:13-8.