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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2020; 41(01): 23-28
DOI: 10.4103/ijmpo.ijmpo_64_19
Original Article

Analysis of Relapsed/Refractory Hodgkin Lymphoma Treated with Autologous Transplantation: A Single-Center Experience

Vishal Kulkarni
Department of Hematology and Medical Oncology, HCG Enterprises Ltd., Bengaluru, Karnataka, India
,
Sulav Sapkota
Department of Hematology and Medical Oncology, HCG Enterprises Ltd., Bengaluru, Karnataka, India
,
Girish V Badarkhe
Department of Hematology and Medical Oncology, HCG Enterprises Ltd., Bengaluru, Karnataka, India
,
BJ Srinivas
Department of Hematology and Medical Oncology, HCG Enterprises Ltd., Bengaluru, Karnataka, India
,
Radheshyam Naik
Department of Hematology and Medical Oncology, HCG Enterprises Ltd., Bengaluru, Karnataka, India
› Author Affiliations Financial support and sponsorship Nil.
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Abstract

Introduction: Hodgkin lymphoma (HL) is one of the common lymphomas with high cure rate. Aims: The aim was to study the outcome of relapsed/refractory HL treated with autologous transplantation. Objectives: The objective was to study the overall survival, overall response, and disease-free survival of the relapsed/refractory HL after autologous transplantation. Methods: It was a retrospective study conducted over a period of 8 years in our center using computer-based database and medical records as the data source. Results: A total of 22 patients were diagnosed with relapsed/refractory HL of which majority of cases were male patients (59%) with a mean age of 29 years (range: 15–57 years) and were Stage 4A (40.9%), with nodular sclerosis (54.5%). The overall response rate was 81.8% with 9.1% complete response, 72.7% partial response, and 4.5% stable disease; the overall survival was 77.92 ± 6.65 months, and disease-free survival was 69.66 ± 8.13 months. Conclusion: Autologous stem cell transplant plays an integral role in the treatment of patients with relapsed/refractory Hodgkin lymphoma.

Keywords

Autologous - Hodgkin - refractory - relapsed


Publication History

Received: 06 March 2019

Accepted: 24 November 2019

Article published online:
23 May 2021

© 2020. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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