CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2020; 41(02): 187-192
DOI: 10.4103/ijmpo.ijmpo_61_19
Original Article

Clinicoradiological Profile and Treatment Outcomes in Prostate Cancer at a Tertiary Care Cancer Center in India

Astha Rajput
Department of Clinical Research, Max Institute of Cancer Care, Max Super Specialty Hospital, New Delhi, India
,
Shaik Maheboob Hussain
Department of Medical Oncology, Max Institute of Cancer Care, Max Super Specialty Hospital, New Delhi, India
,
Neha Sonthwal
Department of Clinical Research, Max Institute of Cancer Care, Max Super Specialty Hospital, New Delhi, India
,
Gagan Gautam
Department of Surgical Oncology, Max Institute of Cancer Care, Max Super Specialty Hospital, New Delhi, India
,
Puneet Ahluwalia
Department of Surgical Oncology, Max Institute of Cancer Care, Max Super Specialty Hospital, New Delhi, India
,
Anirudh Punnakal
Department of Radiation Oncology, Max Institute of Cancer Care, Max Super Specialty Hospital, New Delhi, India
,
Harit Chaturvedi
Department of Surgical Oncology, Max Institute of Cancer Care, Max Super Specialty Hospital, New Delhi, India
,
Pankaj Dougall
Department of Nuclear Medicine, Max Institute of Cancer Care, Max Super Specialty Hospital, New Delhi, India
,
Jaspriya Bal
Department of Nuclear Medicine, Max Institute of Cancer Care, Max Super Specialty Hospital, New Delhi, India
,
Alok Gupta
Department of Medical Oncology, Max Institute of Cancer Care, Max Super Specialty Hospital, New Delhi, India
› Author Affiliations
Financial support and sponsorship Nil.

Abstract

Introduction: Prostate cancer is the most common solid cancer in men and is responsible for 11% of all cancer-related deaths. There are limited data available regarding clinicoradiological (prostate-specific membrane antigen [PSMA]-positron emission tomography [PET]/computed tomography [CT], magnetic resonance imaging, and bone scan) characteristics, treatment outcomes, and correlation of clinicoradiological characteristics with treatment outcomes of prostate cancer patients from India, especially in the era of PSMA-PET/CT scan. Methodology: This was a single center, retrospective, observational study, conducted for 6 months. We retrospectively collected the data of 332 prostate cancer patients treated between January 2015 and December 2017 at our institute. Results: Three hundred and thirty-two patients were enrolled and were divided into three groups depending on the stage and treatment modality, i.e., Group A, B, and C containing 205, 47, and 80 patients, respectively. The median age was 67 years, and the median prostate-specific antigen (PSA) was 19.3 ng/ml. Lower urinary tract symptoms (83.4%) and bone pain (8.1%) were the common presenting symptoms. PSMA-PET/CT scan revealed regional lymph node metastasis in 56.5% patients, bone metastasis in 35.7%, and visceral metastasis in 11.5% patients, respectively. In patients treated with curative intent, radical prostatectomy was performed in 61.74% of patients, whereas radiation therapy was performed in 47 (14.15%) patients. Among those treated with palliative intent, androgen deprivation therapy (ADT) alone (40) was the most preferred therapy followed by the combination of ADT with docetaxel (28) or abiraterone (12). Significantly (P = 0.006), a greater number of patients who were treated with ADT alone progressed to castration-resistant prostate cancer (CRPC) compared to those on combination ADT with either abiraterone or docetaxel. No significant difference was seen in the disease progression when treatment arm containing ADT with docetaxel was compared to ADT with abiraterone. Conclusion: Patients with metastatic disease had a higher median PSA level and also had a higher likelihood of having Gleason score 8–10. Among patients who were treated with palliative intent for metastatic disease, disease progression to CRPC state was significantly higher in those treated with ADT alone compared to those treated with either ADT + docetaxel or ADT + abiraterone.



Publication History

Received: 05 April 2019

Accepted: 19 January 2020

Article published online:
23 May 2021

© 2020. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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