CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2017; 38(02): 116-120
DOI: 10.4103/ijmpo.ijmpo_60_16
Original Article

Evaluation of Cytotoxicity Effects of Oleo-Gum-Resin and Its Essential Oil of Ferula assa‑foetida and Ferulic Acid on 4T1 Breast Cancer Cells

Seyyed Majid Bagheri
Department of Physiology; Neurobiomedical Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
,
Amir Abdian Asl
Department of Immunology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
,
Ali Shams
Department of Immunology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
,
Seyyed Ali Mirghanizadeh-Bafghi
Department of Immunology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
,
Zeynab Hafizibarjin
Department of Physiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
› Author Affiliations
Financial support and sponsorship Nil.

Abstract

Background: Cancer causes significant morbidity and mortality and is a major public health problem worldwide. Breast cancer is a leading cause of cancer-associated mortality in women, and the incidence is also on the rise in the entire world. Medicinal plants have been an important source of several clinically useful anticancer agents. Aim: In this study, we studied the growth inhibitory effect of asafoetida and its essential oil and ferulic acid on antitumor activity using mouse breast cancer cell line. Materials and Methods: For this aim, cells were exposed to these components at different concentrations and for different time durations. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was carried out to characterize the cytotoxicity of the constituents used. Results: Our results showed that all three constituents could inhibit 4T1 cell proliferation. Our MTT assay results showed a significant cytotoxicity effect in a time- and concentration-dependent manner. It also demonstrated that essential oil of asafoetida has a stronger effect in decreasing viability breast cancer cells. Ferulic acid showed a significant effect only at a dose of 500 μg/ml. Conclusions: Based on the results of cellular carried out in this study, we could demonstrate that asafoetida and its essential oil and ferulic acid have inhibitory effect on the growth of breast cancer cell line. As evidenced from these preliminary results, asafoetida and its derivative constituents may be considered as attractive alternatives to serve as lead compounds in drug development for breast cancer as an adjuvant therapy. However, much remains to be done before such agent could be introduced to the clinic.



Publication History

Article published online:
06 July 2021

© 2017. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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