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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2018; 39(01): 100-102
DOI: 10.4103/ijmpo.ijmpo_59_17
Case Report

Childhood Primary Myelofibrosis Presented with Headache, Splenomegaly, and Severe Thrombocytosis: A Case Report

Athanasios Tragiannidis
Department of Pediatric, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece
,
Athanasia Apsemidou
Department of Pediatric, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece
,
Ioannis Liampas
Department of Pediatric, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece
,
Triantafyllia Koletsa
Department of Pathology, Aristotle University of Thessaloniki, Thessaloniki, Greece
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Abstract

Primary myelofibrosis (PMF) is a clonal disorder of a multipotent hematopoietic progenitor cell that occurs predominantly in the elderly age group. We report here an 11-year-old girl who presented with headache, fever, and splenomegaly. Full blood cell count revealed severe thrombocytosis. Laboratory and radiology examinations excluded the diagnosis of essential/reactive thrombocytosis. Bone marrow biopsy showed megakaryocytic hyperplasia, reticulin and collagen fibrosis, and erythroid and myeloid hypoplasia, findings compatible to PMF. The patient was put symptomatically on hydroxyurea and hydration due to thrombocytosis and platelet number decreased. Hematopoietic stem cell transplantation was scheduled to avoid delaying definitive therapy and secondary complications such as infections and transfusion dependency. To the best of our knowledge, this is the first reported case of PMF in childhood in Greece.

Keywords

Childhood - primary myelofibrosis - thrombocytosis


Publication History

Article published online:
23 June 2021

© 2018. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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