CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2018; 39(01): 52-57
DOI: 10.4103/ijmpo.ijmpo_49_17
Original Article

CDX2 Expression in Gastric Carcinoma: A Clinicopathological Study

Aniket Halder
Department of GI-Pathology, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India
,
Mousumi Kundu
Department of Pathology, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India
,
Ram Narayan Das
Department of Pathology, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India
,
Uttara Chatterjee
Department of Pathology, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India
,
Chhanda Datta
Department of Pathology, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India
,
Manoj Kr Choudhuri
Department of Pathology, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India
,
Bitan Chatterjee
Department of General Surgery, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India
› Author Affiliations
Financial support and sponsorship Nil.

Abstract

Background: Gastric cancer accounts for 7.8% of cancers worldwide and adenocarcinoma is the commonest histological type. Both gastric and intestinal phenotypic cell markers are expressed in gastric carcinomas. CDX2 is an intestinal transcription factor, which can be demonstrated in intestinal metaplasia and gastric carcinomas of the intestinal type. Unlike colorectal carcinomas, the role of CDX2 in gastric carcinomas as a prognostic variable is yet to be established. Ki-67 is a transcription factor expressed in the growth and synthetic phases of the cell cycle. Aims and Objectives: The aims of the study were to analyze CDX2 expression and Ki-67 labeling index in different histological types of gastric carcinomas and their relationship with the patients' clinicopathological parameters. Materials and Methods: A total of 50 gastric carcinoma cases were evaluated histologically and phenotypically, along with assessment of CDX2 expression and Ki-67 labeling index. Gastric carcinomas were grouped into intestinal and diffuse types, according to Lauren classification. A semiquantitative microscopic evaluation of CDX2 expression and Ki-67 labeling index was performed and correlated with the patients' clinicopathological parameters. Results: Increased CDX2 expression correlated with higher proportion of intestinal type gastric carcinomas and a lower proportion of lymph node metastasis, lymphovascular and perineural invasion. On the other hand, high Ki-67 labeling index was found in high grade tumors with lymphovascular invasion. Conclusions: The results of our study suggest that CDX2 might be a useful marker in predicting the prognosis of patients with gastric carcinoma. Accordingly, Ki-67 index seems to be useful in identifying a group of patients with aggressive tumors.



Publication History

Article published online:
23 June 2021

© 2018. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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