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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2019; 40(03): 402-405
DOI: 10.4103/ijmpo.ijmpo_33_18
Original Article

MUC2 and MUC5AC Expression in Colon Cancer: A Preliminary Report from South India

R Jayanth
Department of Medical and Surgical Gastroenterology, Stanley Medical College and Hospital, Chennai, Tamil Nadu, India
,
H Devaraj
Glycotechnology Centre, AC Tech, University of Madras, Chennai, Tamil Nadu, India
,
R Surendran
Department of Medical and Surgical Gastroenterology, Stanley Medical College and Hospital, Chennai, Tamil Nadu, India
,
Mayank Jain
Gleneagles Global Health City, Chennai, Tamil Nadu, India
,
Jayanthi Venkataraman
Department of Medical and Surgical Gastroenterology, Stanley Medical College and Hospital, Chennai, Tamil Nadu, India
Gleneagles Global Health City, Chennai, Tamil Nadu, India
› Author Affiliations Financial support and sponsorship Nil.
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Abstract

Background: There is scanty data from India regarding MUC protein expression from colorectal cancers (CRC) among Indian patients. Aim of the Study: The aim of this study is to assess the alterations in the expression of MUC2 and MUC5AC in 25 patients with CRC by site of the tumor location and differentiation at histology. Materials and Methods: Patients with proven adenocarcinoma of the colon alone were included for the study. Biopsy specimens obtained from tumorous lesions in the colon were classified based on histopathology as well differentiated, moderately, and poorly differentiated adenocarcinoma. Immunohistochemistry was done in the 4 μm thick sections to identify the expression of MUC2 and MUC5AC mucins. Results: MUC2 was uniformly expressed with near similar intensity while MUC5 was moderately (56%) to highly expressed (36%) in mucinous tumors. In nonmucinous tumors, MUC2 was least expressed (68%) with a significant expression on MUC5AC (88%). Except for rectosigmoid growth which had greater expression of MUC5AC (31%), both proximal and distal carcinomas had significant MUC2 and MUC5AC expression. Conclusion: MUC2 and MUC5AC are expressed in colonic cancers, the former showing mildtomoderate expression and the latter moderatetointense expression. The expression is more in mucinous adenocarcinoma.

Keywords

Cancer - colon - India - mucin


Publication History

Received: 09 February 2018

Accepted: 12 September 2018

Article published online:
03 June 2021

© 2019. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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