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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2018; 39(03): 363-367
DOI: 10.4103/ijmpo.ijmpo_31_17
Review Article

Erythema Multiforme: A Mysterious Lesion!

TG Shrihari
Department of Oral Medicine and Radiology, Krishnadevaraya College of Dental Sciences and Hospital, Bengaluru, Karnataka, India
,
Shishir Ram Shetty
Department of Oral Medicine and Radiology, Gulf Medical University, Ajman, U A E
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Abstract

The term “erythema multiforme (EM)” includes a wide and controversial variety of clinical expressions at the present time. This study revises the EM minor characteristics according to the most important publications found in literature. EM is a distinct dermatologic hypersensitivity pathology characterized by cutaneous or mucous lesions, and eventually, it can also involve both. In the EM minor, only one mucous membrane is affected and usually is the oral mucosa. When occur in the skin, the lesions usually appear symmetrically in the extremities and may exhibit several forms; hence, the name EM, in a target form, could be continuous or recurrent and none additional systemic involvement is present for both cases. Nowadays, many authors separate etiologically the several manifestations of the EM spectrum. However, no clinical definition is still accepted thoroughly, making more difficult the comparisons of etiological and clinical aspects, histopathological studies, and therapeutic protocols. For the present work, we tried to elucidate through an extensive literature revision, some historical and current aspects of EM, focusing mainly the EM minor and its frequent association to herpes simplex virus, with their diagnostic characteristics and current therapeutics, to facilitate the physician understanding, and to favor future researches about this mysterious disease.

Keywords

Epidermal necrolysis toxic - herpes-associated erythema multiforme - herpes simplex virus - Stevens–Johnson syndrome


Publication History

Article published online:
17 June 2021

© 2018. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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