CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2019; 40(S 01): S160-S162
DOI: 10.4103/ijmpo.ijmpo_250_17
Case Report

Pleurodesis in Pulmonary Langerhans Cell Histiocytosis in Children: A Life-Saving Measure

Anand Prakash
Division of Pediatric Hematology-Oncology, St. John’s Medical College Hospital, Bengaluru, Karnataka, India
,
Tarangini Durugappa
Division of Pediatric Hematology-Oncology, St. John’s Medical College Hospital, Bengaluru, Karnataka, India
,
Priya Ramachandran
Department of Pulmonary Medicine, St. John’s Medical College Hospital, Bengaluru, Karnataka, India
,
AV Lalitha
Division of Pediatric Intensive Care, St. John’s Medical College Hospital, Bengaluru, Karnataka, India
› Author Affiliations
Financial support and sponsorship Nil.

Abstract

Isolated pulmonary Langerhans cell histiocytosis (LCH) is uncommon in children. Often recurrent pneumothorax complicates therapy and contributes to morbidity. Chemotherapy does not always prevent the complications of pneumothorax. We report here a young girl with isolated pulmonary LCH who presented with respiratory failure, successfully treated with chemotherapy, and pleurodesis. We report this case to highlight the use of pleurodesis in this setting.



Publication History

Article published online:
24 May 2021

© 2019. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 
  • References

  • 1 Ha SY, Helms P, Fletcher M, Broadbent V, Pritchard J. Lung involvement in Langerhans’ cell histiocytosis: Prevalence, clinical features, and outcome. Pediatrics 1992; 89: 466-9
  • 2 Al-Trabolsi HA, Alshehri M, Al-Shomrani A, Shabanah M, Al-Barki AA. “Primary” pulmonary langerhans cell histiocytosis in a two-year-old child: Case report and literature review. J Pediatr Hematol Oncol 2006; 28: 79-81
  • 3 Varkki S, Tergestina M, Bhonsle VS, Moses PD, Mathai J, Korula S. et al. Isolated pulmonary langerhans cell histiocytosis. Indian J Pediatr 2013; 80: 700-3
  • 4 Patra A, Bhattacharyay SK, Maji A, Mandal A. Pulmonary langerhans cell histiocytosis causing spontaneous bilateral pneumothorax in a child. Egypt J Int Med 2015; 27: 38-9
  • 5 Dejima H, Morita S, Takahashi Y, Matsutani N, Iinuma H, Kondo F. et al. A case of invasive langerhans cell histiocytosis localizing only in the lung and diagnosed as pneumothorax in an adolescent female. Int J Clin Exp Pathol 2015; 8: 3354-7
  • 6 Asilsoy S, Yazici N, Demir S, Erbay A, Koçer E, Sarıalioğlu F. et al. A different cause for respiratory disorder in children: Cases with pulmonary langerhans cell histiocytosis. Clin Respir J 2017; 11: 193-9
  • 7 Sharma BB. Miliary nodules on chest radiographs: A diagnostic dilemma. Lung India 2015; 32: 518-20
  • 8 Bano S, Chaudhary V, Narula MK, Anand R, Venkatesan B, Mandal S. et al. Pulmonary langerhans cell histiocytosis in children: A spectrum of radiologic findings. Eur J Radiol 2014; 83: 47-56
  • 9 Ko SM, Choe BK, Kim HS, Lee HJ, Kwon KY. Atypical radiological manifestations of pulmonary langerhans cell histiocytosis in a 12-year-old girl. Br J Radiol 2008; 81: e238-41
  • 10 Sharma N, Kumar P. Miliary tuberculosis with bilateral pneumothorax: A rare complication. Indian J Chest Dis Allied Sci 2002; 44: 125-7
  • 11 Wammanda RD, Ameh EA, Ali FU. Bilateral pneumothorax complicating miliary tuberculosis in children: Case report and review of the literature. Ann Trop Paediatr 2003; 23: 149-52
  • 12 Khan NA, Akhtar J, Baneen U, Shameem M, Ahmed Z, Bhargava R. et al. Recurrent pneumothorax: A rare complication of miliary tuberculosis. N Am J Med Sci 2011; 3: 428-30
  • 13 Gao L, Li H, Li G, Liu W, Li J, Zhang W. et al. Pulmonary langerhans cell histiocytosis with cervical lymph node involvement, and coexistence with pulmonary tuberculosis and right pneumothorax: A case report and review of literature. Int J Clin Exp Pathol 2015; 8: 2146-52
  • 14 Dey A, Bhuniya S, Datta Chaudhuri A, Pandit S, Saha-Dutta Chowdhury M, Sengupta A. et al. Iodopovidone pleurodesis: Experience of a tertiary hospital in Kolkata. Singapore Med J 2010; 51: 163-5
  • 15 Agarwal R, Khan A, Aggarwal AN, Gupta D. Efficacy and safety of iodopovidone pleurodesis: A systematic review & meta-analysis. Indian J Med Res 2012; 135: 297-304
  • 16 Valliani L, Kanwar VS, Schwartz A. Isolated pulmonary langerhans cell histiocytosis with recurrent bilateral pneumothoraces treated with chemotherapy and chemical pleurodesis. Pediatr Blood Cancer 2009; 53: 128-9
  • 17 Verma S, Jondhale S, Bansal D, Radotra BD, Singhi SC. Iodopovidone pleurodesis for isolated pulmonary langerhan’s cell histiocytosis in a two year old child. Indian J Pediatr 2014; 81: 715-8
  • 18 Abdul Aziz DA, Abdul Rahman NA, Tang SF, Abdul Latif H, Zaki FM, Annuar ZM. et al. Total pleurectomy as the surgical treatment for recurrent secondary spontaneous pneumothorax in a child with severe pulmonary langerhans cells histiocytosis. BMJ Case Rep 2011;2011. pii: bcr0920114734.
  • 19 Braier J, Latella A, Balancini B, Castaños C, Goldberg J. Isolated pulmonary langerhans cell histiocytosis presenting with recurrent pneumothorax. Pediatr Blood Cancer 2007; 48: 241-4