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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2020; 41(04): 591-595
DOI: 10.4103/ijmpo.ijmpo_245_19
Case Reports and Review of Literature

Primary Hepatoid Adenocarcinoma of the Lung: A Study of Two Cases with Review of Literature

Contributor(s):
Ashwini Nargund
Department of Pathology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India
,
Mohit Agrawal
Department of Pathology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India
,
Priya Dharmalingam
Department of Pathology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India
,
Usha Amirtham
Department of Pathology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India
,
Malathi MukundaPai
Department of Pathology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India
› Author Affiliations Financial support and sponsorship Nil.
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Abstract

Primary hepatoid adenocarcinoma (HAC) is a rare extrahepatic adenocarcinoma with morphological and phenotypical resemblance to hepatocellular carcinoma (HCC). It can occur in lung, stomach, gallbladder, pancreas, ovary, and uterus, with most common site being stomach. Morphological features of primary HAC of the lung are similar to HCC, so exclusion of metastatic HCC is necessary. In this report, we describe two cases of elderly men with primary pulmonary HAC who presented in advanced clinical stage and diagnosed by fine-needle aspiration cytology with immunohistochemistry. Both patients succumbed to death despite starting first cycle of chemotherapy.

Keywords

Cell block - fine-needle aspiration cytology - hepatoid adenocarcinoma - immunohistochemistry - lung


Publication History

Received: 04 December 2019

Accepted: 30 June 2020

Article published online:
17 May 2021

© 2020. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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