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DOI: 10.4103/ijmpo.ijmpo_241_18
Rapid Weight Gain: An Unusual Presentation of Leukemia
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Abstract
Neurological manifestations of leukemia can be due to direct effects of the malignancy or due to the indirect effects of infection or therapy. An 11-year-old boy presented with recent-onset weight gain with papilledema and a history of tuberculosis contact. Neuroimaging and initial microscopic examination of the cerebrospinal fluid (CSF) did not aid in the diagnosis of central nervous system leukemia. He was started on antitubercular treatment yet deteriorated. Repeat CSF analysis when subjected to cytospin and flow cytometry confirmed the diagnosis of B cell acute lymphoblastic leukemia (ALL). Although there have been reports of relapsed ALL presenting as obesity, isolated rapid changes in weight at initial presentation are a very rare and unusual manifestation of ALL. To the best of our knowledge, this is the first such report.
Publication History
Received: 03 November 2018
Accepted: 17 September 2019
Article published online:
23 May 2021
© 2020. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)
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References
- 1 Laningham FH, Kun LE, Reddick WE, Ogg RJ, Morris EB, Pui CH. et al. Childhood central nervous system leukemia: Historical perspectives, current therapy, and acute neurological sequelae. Neuroradiology 2007; 49: 873-88
- 2 Asthana S, Labani S, Mehrana S, Bakhshi S. Incidence of childhood leukaemia and lymphoma in India. Pediatr Hematol Oncol J 2018; 3: 115-20
- 3 Chamberlain MC. Leukemia and the nervous system. Curr Oncol Rep 2005; 7: 66-73
- 4 Iughetti L, Bruzzi P, Predieri B, Paolucci P. Obesity in patients with acute lymphoblastic leukemia in childhood. Ital J Pediatr 2012; 38: 4
- 5 Zhang LD, Li YH, Ke ZY, Huang LB, Luo XQ. Obesity as the initial manifestation of central nervous system relapse of acute lymphoblastic leukemia: Case report and literature review. J Cancer Res Ther 2012; 8: 151-3
- 6 Roma AA, Garcia A, Avagnina A, Rescia C, Elsner B. Lymphoid and myeloid neoplasms involving cerebrospinal fluid: Comparison of morphologic examination and immunophenotyping by flow cytometry. Diagn Cytopathol 2002; 27: 271-5
- 7 Beatrice AM, Selvan C, Mukhopadhyay S. Pituitary dysfunction in infective brain diseases. Indian J Endocrinol Metab 2013; 17: S608-11
- 8 Ulu EM, Töre HG, Bayrak A, Güngör D, Coşkun M. MRI of central nervous system abnormalities in childhood leukemia. Diagn Interv Radiol 2009; 15: 86-92