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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2019; 40(S 01): S120-S122
DOI: 10.4103/ijmpo.ijmpo_241_17
Case Report

Post-transplant Epstein–Barr Virus-Related Lymphoproliferative Disorder: A Case Report and Review of Literature

Vasu Babu Goli
Departments of Medical Oncology and Bone Marrow Transplantation, Jaslok Hospital and Research Center, Mumbai, Maharashtra, India
,
Preet Shah
Departments of Gastroenterology, Jaslok Hospital and Research Center, Mumbai, Maharashtra, India
,
M Ganapathi Bhat
Departments of Medical Oncology and Bone Marrow Transplantation, Jaslok Hospital and Research Center, Mumbai, Maharashtra, India
,
Aabha Nagral
Departments of Gastroenterology, Jaslok Hospital and Research Center, Mumbai, Maharashtra, India
› Author Affiliations Financial support and sponsorship Nil.
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Abstract

Post transplant lympho-proliferative disorders (PTLD) are a serious complications of solid organ transplantation. Solid organ recipients have an increased risk of cancers related to immunosuppression and the Epstein-Barr virus (EBV)-in particular lymphomas and majority of PTLD are of B-cell origin. The occurrence of PTLD in solid organ recipients can have varied clinical presentation and histopathological features. Although lymphoproliferative disorders were initially reported to be rare complication of transplantation, observations in past decade shown that they are common and are associated with poor outcomes. We report the case of a patient with deceased donor liver transplantation for Budd-chiari syndrome, who presented, four years after liver transplantation, with an EBV-associated Burkitt lymphoma with gastrointestinal and extensive skeletal metastasis recovered completely after adjustment of immunosuppressive treatment and chemo-immunotherapy. Our suggestion is that patients with the risk factors like T-cell depleting agents or increasing immunosuppressive therapy must be closely monitored with quantitative EBV PCR. Improvements in immunosuppressive strategies for transplantation and advances in treatment resulted in improved outcomes and long term survival for patients with PTLD.

Keywords

Computed tomography - Epstein–Barr virus - positron emission tomography-computed tomography - post-transplant lymphoproliferative disorders


Publication History

Article published online:
24 May 2021

© 2019. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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