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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2018; 39(04): 536-538
DOI: 10.4103/ijmpo.ijmpo_23_17
Case Report

Undifferentiated Carcinoma of the Uterine Cervix with Evidence of Its Origin from Small-Cell Neuroendocrine Carcinoma

Rajeshwari K Muthusamy
Department of Pathology, Kovai Medical Center and Hospital, Coimbatore, Tamil Nadu, India
,
Sangita S Mehta
Department of Pathology, Kovai Medical Center and Hospital, Coimbatore, Tamil Nadu, India
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Abstract

Neuroendocrine carcinoma (NEC) of the uterine cervix is an uncommon aggressive tumor, comprises <5% of the cervical malignancies. Undifferentiated carcinoma of the cervix, described by the World Health Organization Classification of Tumors as a distinct entity, is extremely rare with no histologic evidence of differentiation. Immunohistochemistry with p63 and neuroendocrine markers helps in delineating the type as undifferentiated squamous cell carcinoma or NEC. NEC of the uterine cervix behaves biologically like any other cervical malignancy, has an association with human papillomavirus, and is similar to NEC of any possible site with early metastasis and poorer survival. We present a case of 45-year-old premenopausal female with undifferentiated carcinoma of the uterine cervix originating from small-cell NEC proven by the presence of differentiated component in the proximity of undifferentiated tumor and by the immunohistochemistry.

Keywords

Human papillomavirus - neuroendocrine carcinoma - undifferentiated carcinoma - uterine cervix


Publication History

Article published online:
17 June 2021

© 2018. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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  • References

  • 1 Gardner GJ, Reidy-Lagunes D, Gehrig PA. Neuroendocrine tumors of the gynecologic tract: A Society of Gynecologic Oncology (SGO) clinical document. Gynecol Oncol 2011; 122: 190-8
    CrossrefPubMedGoogle Scholar
  • 2 Nucci MR, Lee KR, Crum CP. Tumors of the female genital tract, part E cervix. In: Fletcher CD. editor Diagnostic Histopathology of Tumors. 4th ed. 1. Philadelphia: Elsevier Saunders; 2013: 829-30
    Google Scholar
  • 3 Stoler MH, Mills SE, Gersell DJ, Walker AN. Small-cell neuroendocrine carcinoma of the cervix. A human papillomavirus type 18-associated cancer. Am J Surg Pathol 1991; 15: 28-32
    CrossrefPubMedGoogle Scholar
  • 4 Colgan TJ, Kim I, Hirschowitz L, McCluggage WG. Neuroendocrine tumours. In: Kurman RJ, Carcangiu ML, Herrington CS, Young RH. editors WHO Classification of Tumours of Female Reproductive Organs. 4th ed. Lyon: IARC; 2014: 196-8
    Google Scholar
  • 5 Colgan TJ, Kim KR, Hirschowitz L, McCluggage WG. Other epithelial tumours. In: Kurman RJ, Carcangiu ML, Herrington CS, Young RH. editors WHO Classification of Tumours of Female Reproductive Organs. 4th ed. Lyon: IARC; 2014: 194-6
    Google Scholar
  • 6 Lee JM, Lee KB, Nam JH, Ryu SY, Bae DS, Park JT. et al. Prognostic factors in FIGO stage IB-IIA small cell neuroendocrine carcinoma of the uterine cervix treated surgically: Results of a multi-center retrospective Korean study. Ann Oncol 2008; 19: 321-6
    CrossrefPubMedGoogle Scholar
  • 7 Bifulco G, Mandato VD, Giampaolino P, Piccoli R, Insabato L, De Rosa N. et al. Small cell neuroendocrine cervical carcinoma with 1-year follow-up: Case report and review. Anticancer Res 2009; 29: 477-84
    Google Scholar
  • 8 Wang KL, Yang YC, Wang TY, Chen JR, Chen TC, Chen HS. et al. Neuroendocrine carcinoma of the uterine cervix: A clinicopathologic retrospective study of 31 cases with prognostic implications. J Chemother 2006; 18: 209-16
    CrossrefPubMedGoogle Scholar
  • 9 Viswanathan AN, Deavers MT, Jhingran A, Ramirez PT, Levenback C, Eifel PJ. et al. Small cell neuroendocrine carcinoma of the cervix: Outcome and patterns of recurrence. Gynecol Oncol 2004; 93: 27-33
    CrossrefPubMedGoogle Scholar
  • 10 Chan JK, Loizzi V, Burger RA, Rutgers J, Monk BJ. Prognostic factors in neuroendocrine small cell cervical carcinoma: A multivariate analysis. Cancer 2003; 97: 568-74
    CrossrefPubMedGoogle Scholar