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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2017; 38(03): 360-362
DOI: 10.4103/ijmpo.ijmpo_23_16
Case Report

A Case Report of Newly Diagnosed Epithelial Ovarian Carcinoma Presenting with Spontaneous Tumor Lysis Syndrome and Its Successful Management with Rasburicase

Deepak Kumar Shukla
Department of Medical Oncology, Manipal Hospital, Jaipur, Rajasthan, India
,
Dinesh Gupta
Department of Surgical Oncology, Manipal Hospital, Jaipur, Rajasthan, India
,
Arun Aggarwal
Department of Radiation Oncology, Adhar Hospital, Hisar, Haryana, India
,
Deepak Kumar
Department of Radiation Oncology, OP Jindal Institute of Cancer and Research, Hisar, Haryana, India
› Author Affiliations Financial support and sponsorship Nil.
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Abstract

Tumor Lysis Syndrome (TLS) commonly occurs in hematological malignancies, but it is very rare in patients with a solid tumor. In cases of solid tumors, TLS usually occurs spontaneously or after the initiation of anticancer therapy, and it has a high mortality rate. This syndrome consists of a constellation of laboratory findings such as hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia known as laboratory TLS. When clinical complications such as seizures, acute renal failure, and cardiac dysrhythmias occur in patients with laboratory TLS, the syndrome is called clinical TLS. The present case report is sixth in the series and probably the first case report of spontaneous TLS in a newly diagnosed patient of epithelial ovarian cancer and also shows the effectiveness of single dose (1.5 mg) of rasburicase along with adequate hydration to rapidly reverse TLS and also timely initiation of definitive treatment. The patient was then able to complete successfully the planned neoadjuvant chemotherapy and surgery without any long-term sequela.

Keywords

Carcinoma ovary - rasburicase - spontaneous tumor lysis syndrome


Publication History

Article published online:
04 July 2021

© 2017. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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