Download PDF
CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2019; 40(S 01): S123-S125
DOI: 10.4103/ijmpo.ijmpo_239_17
Case Report

An Unusual Tumor of the Vagina

Archana Archana
Departments of Gynaecology, Vardhmaan Mahaveer Medical College and Safdarjung Hospital, New Delhi, India
,
Saritha Shamsunder
Departments of Gynaecology, Vardhmaan Mahaveer Medical College and Safdarjung Hospital, New Delhi, India
,
Amit Yadav
Departments of Pathology, Vardhmaan Mahaveer Medical College and Safdarjung Hospital, New Delhi, India
,
Sunita Malik
Departments of Gynaecology, Vardhmaan Mahaveer Medical College and Safdarjung Hospital, New Delhi, India
› Author Affiliations Financial support and sponsorship Nil.
› Further Information
   Permissions and Reprints

Abstract

A 28-year-old female came with complaints of swelling in the perineal area; examination revealed a nontender and fixed mass of approximately 4 cm × 3 cm on the right vulvovaginal junction extending into the vaginal wall. Wide excision of the mass was performed; histopathological examination revealed features suggestive of Merkel cell carcinoma of vagina.

Keywords

Cytokeratin - Merkel cell carcinoma - vulvovaginal mass


Publication History

Article published online:
24 May 2021

© 2019. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 

  • References

  • 1 Koljonen V. Merkel cell carcinoma. World J Surg Oncol 2006; 4: 7
    CrossrefPubMedGoogle Scholar
  • 2 Barrett AW, Cort EM, Patel P, Berkovitz BK. An immunohistological study of cytokeratin 20 in human and mammalian oral epithelium. Arch Oral Biol 2000; 45: 879-87
    CrossrefPubMedGoogle Scholar
  • 3 Hilliges M, Falconer C, Ekman-Ordeberg G, Johansson O. Innervation of the human vaginal mucosa as revealed by PGP 9.5 immunohistochemistry. Cells Tissues Organs 1995; 153: 119-26
    CrossrefPubMedGoogle Scholar
  • 4 Skelton HG, Smith KJ, Hitchcock CL, McCarthy WF, Lupton GP, Graham JH. et al. Merkel cell carcinoma: Analysis of clinical, histologic, and immunohistologic features of 132 cases with relation to survival. J Am Acad Dermatol 1997; 37: 734-9
    CrossrefPubMedGoogle Scholar
  • 5 Moll R, Löwe A, Laufer J, Franke WW. Cytokeratin 20 in human carcinomas. A new histodiagnostic marker detected by monoclonal antibodies. Am J Pathol 1992; 140: 427-47
    PubMedGoogle Scholar
  • 6 Chan JK, Suster S, Wenig BM, Tsang WY, Chan JB, Lau AL. et al. Cytokeratin 20 immunoreactivity distinguishes merkel cell (primary cutaneous neuroendocrine) carcinomas and salivary gland small cell carcinomas from small cell carcinomas of various sites. Am J Surg Pathol 1997; 21: 226-34
    CrossrefPubMedGoogle Scholar
  • 7 Devoe K, Weidner N. Immunohistochemistry of small round-cell tumors. Semin Diagn Pathol 2000; 17: 216-24
    PubMedGoogle Scholar
  • 8 Nagao T, Gaffey TA, Olsen KD, Serizawa H, Lewis JE. Small cell carcinoma of the major salivary glands: Clinicopathologic study with emphasis on cytokeratin 20 immunoreactivity and clinical outcome. Am J Surg Pathol 2004; 28: 762-70
    PubMedGoogle Scholar
  • 9 Finan MA, Barre G. Bartholin’s gland carcinoma, malignant melanoma and other rare tumours of the vulva. Best Pract Res Clin Obstet Gynaecol 2003; 17: 609-33
    CrossrefPubMedGoogle Scholar
  • 10 Iavazzo C, Terzi M, Arapantoni-Dadioti P, Dertimas V, Vorgias G. Vulvar merkel carcinoma: A case report. Case Rep Med 2011; 2011: 546972
    CrossrefPubMedGoogle Scholar