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DOI: 10.4103/ijmpo.ijmpo_238_17
Hodgkin Lymphoma Presenting as Immune Thrombocytopenia
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Abstract
Immune thrombocytopenia (ITP) in lymphoid malignancies has been observed primarily in relation to chronic lymphoproliferative disorders. ITP in Hodgkin lymphoma (HL) is a rare presentation, most often reported at follow-up. We report a case of a 12-year-old female presenting with symptomatic thrombocytopenia at the time of diagnosis of HL. The patient had stage III B bulky disease with HL mixed cellularity subtype on histology. The patient was treated with adriamycin, bleomycin, vinblastine, and dacarbazine regime along with local radiation therapy and is in complete remission at 18 months of follow-up. The treatment of underlying lymphoma in such cases resolves thrombocytopenia.
Publication History
Article published online:
03 June 2021
© 2019. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).
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References
- 1 Visco C, Rodeghiero F. Immune thrombocytopenia in lymphoproliferative disorders. Hematol Oncol Clin North Am 2009; 23: 1261-74
- 2 Cines DB, Bussel JB, Liebman HA, Luning Prak ET. The ITP syndrome: Pathogenic and clinical diversity. Blood 2009; 113: 6511-21
- 3 Jain M, Oberoi G, Kumar R, Kumar A. Erythrovirus B19 induced persistent bicytopenia in a healthy child. Rev Bras Hematol Hemoter 2017; 39: 278-80
- 4 Landgren O, Engels EA, Pfeiffer RM, Gridley G, Mellemkjaer L, Olsen JH. et al. Autoimmunity and susceptibility to Hodgkin lymphoma: A population-based case-control study in Scandinavia. J Natl Cancer Inst 2006; 98: 1321-30
- 5 Dimou M, Angelopoulou MK, Pangalis GA, Georgiou G, Kalpadakis C, Pappi V. et al. Autoimmune hemolytic anemia and autoimmune thrombocytopenia at diagnosis and during follow-up of Hodgkin lymphoma. Leuk Lymphoma 2012; 53: 1481-7
- 6 Dahlqvist C, Betomvuko P, Verdebout JM, Mineur P. Immune thrombocytopenic purpura at the diagnosis of Hodgkin disease. Acta Clin Belg 2010; 65: 41-3
- 7 Ertem M, Uysal Z, Yavuz G, Gözdaşoǧlu S. Immune thrombocytopenia and hemolytic anemia as a presenting manifestation of Hodgkin disease. Pediatr Hematol Oncol 2000; 17: 181-5
- 8 Lechner K, Chen YA. Paraneoplastic autoimmune cytopenias in Hodgkin lymphoma. Leuk Lymphoma 2010; 51: 469-74