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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2019; 40(03): 435-439
DOI: 10.4103/ijmpo.ijmpo_233_17
Case Report

Pediatric Primary Pleural Synovial Sarcoma: A Unique Case Report with Brief Review of Literature

Anant Vatsayan
Department of Pediatric Hematology/Oncology, Bone Marrow Transplantation and Cellular Therapy, Memorial Sloan Kettering Cancer Center, NY, USA
,
Ajay Gupta
Department of Pediatric Hematology/Oncology, UH Rainbow Babies and Children's Hospital, Cleveland, Ohio, USA
,
Sharazad Saab
Department of Pathology, UH Rainbow Babies and Children's Hospital, Cleveland, Ohio, USA
,
Agne Petrosiute
Department of Pediatric Hematology/Oncology, UH Rainbow Babies and Children's Hospital, Cleveland, Ohio, USA
› Author Affiliations Financial support and sponsorship Nil.
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Abstract

Synovial sarcoma (SS) primary to the pleura is an extremely rare tumor. So far, only nine cases have been reported in pediatric patients. However, none of these patients was found to have a conglomeration of tumors. Here, we report a case of 16-year-old female with monophasic SS and synchronous occurrence of left paraspinal ganglioneuroma and a right paraovarian cystadenoma. A next-generation sequencing genetic panel revealed a novel variant of unknown significance in the MET gene. The occurrence of multiple different tumors in a young patient with a novel genetic variant in a known oncogene (MET) may suggest a possibility of a hitherto unknown cancer predisposition syndrome. We also present a brief review of primary pleural SS reported in pediatric patients.

Keywords

Children - primary pleural synovial sarcoma - synovial sarcoma


Publication History

Received: 26 November 2017

Accepted: 23 March 2018

Article published online:
03 June 2021

© 2019. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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