Investigation of Vitamin D Receptor Gene Polymorphism in Pediatric Patients with Brain Cancer

Baris Yilmaz; Gulnur Ayse Tokuc; Ahmet Koc; Edanur Yesil

doi:10.4103/ijmpo.ijmpo_22_16

Indian Journal of Medical and Paediatric Oncology, Table of Contents

CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2017; 38(02): 128-132
DOI: 10.4103/ijmpo.ijmpo_22_16

Original Article

Investigation of Vitamin D Receptor Gene Polymorphism in Pediatric Patients with Brain Cancer

Baris Yilmaz

Division of Paediatric Hematology and Oncology, Marmara University Education and Research Hospital, Istanbul, Turkey

,

Gulnur Ayse Tokuc

Division of Paediatric Hematology and Oncology, Marmara University Education and Research Hospital, Istanbul, Turkey

,

Ahmet Koc

Division of Paediatric Hematology and Oncology, Marmara University Education and Research Hospital, Istanbul, Turkey

,

Edanur Yesil

Division of General Paediatrics, Marmara University Education and Research Hospital, Istanbul, Turkey

› Author Affiliations

Abstract

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Abstract

Aim: In recent years, it is believed that Vitamin D may play a protective role in some cancer types. Certain regions of the Vitamin D receptor (VDR) gene may show a genetic difference in structure. The most frequent polymorphisms in this gene are in Taq-1, Fok-1, and Bsm-1 regions. Some adult cancer types are associated with VDR gene polymorphism such as; colorectal carcinoma, breast carcinoma, and prostate carcinoma. Reviewing the medical literature, no such study had been done on children so far. Materials and Methods: We investigated the association of the three most common gene polymorphisms (Taq-1, Fok-1, and Bsm-1 regions) in VDR gene in 32 children with brain tumors and forty control healthy volunteers. Results: We could not find any relationship between childhood brain tumors and VDR gene polymorphism in these three regions. Conclusion: The present results suggest that the Taq-1, Fok-1, and Bsm-1 polymorphism in the VDR gene and pediatric brain cancers have no association.

Keywords

Brain cancers - childhood - polymorphism - Vitamin D receptor

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References

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