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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2018; 39(03): 408-412
DOI: 10.4103/ijmpo.ijmpo_21_17
Case Report

Sclerosing Ovarian Tumor with Disrupted Morphology: Significance of Ancillary Tests in Resolving Diagnostic Dilemma

Shalinee Rao
Department of Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India
,
Susruthan Muralitharan
Department of Pathology, Sri Ramachandra Medical College and Research Institute, Chennai, Tamil Nadu, India
,
Cunnigaiper Dhanasekharan Narayanan
Department of Surgery, Sri Ramachandra Medical College and Research Institute, Chennai, Tamil Nadu, India
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Abstract

Sclerosing stromal tumor is an uncommon subtype of sex cord–stromal tumor of the ovary. It occurs in young females who present with pelvic pain and menstrual irregularities. We present a case of an 18-year-old female who was brought to emergency room with a history of blunt trauma abdomen after road traffic accident. A diagnosis of hemoperitoneum was made, and the patient underwent emergency exploratory laparotomy. An incidental right ovarian mass was found which was removed and sent for histopathological examination. Histomorphology of this lesion showed variable findings with extensive edema and paucicellularity. Few thin wall blood vessels were also observed. The possible differential diagnosis on gross and microscopic examination included sclerosing stromal tumor, fibroma, thecomas, granulosa cell tumor, and edema of the ovary. In view of diagnostic dilemma, special stains for collagen and reticulin were done. In addition, immunohistochemistry (IHC) for CD99, smooth muscle actin, and desmin was put up. A diagnosis of sclerosing tumor of the ovary was made based on histomorphology and findings of ancillary tests. In general, ancillary tests are not required to diagnose sclerosing ovarian tumor as it has characteristic histological features. This case highlights the usefulness of special stains and IHC in sex cord tumors with overlapping microscopic features.

Keywords

Atypical - histomorphology - immunohistochemistry - reticulin stain - sclerosing stromal tumor


Publication History

Article published online:
17 June 2021

© 2018. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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