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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2018; 39(03): 292-296
DOI: 10.4103/ijmpo.ijmpo_203_16
Original Article

Obesity and Breast Cancer: Association of Serum Adiponectin, Leptin, and Adiponectin–Leptin Ratio as Risk Biomarkers

Madhav Danthala
Department of Medical Oncology, Nizam's Institute of Medical Sciences, Panjagutta, Hyderabad, Telangana, India
,
Gogulamudi Ratna Rajesh
Department of Biochemistry, Nizam's Institute of Medical Sciences, Panjagutta, Hyderabad, Telangana, India
,
Sadashivudu Gundeti
Department of Medical Oncology, Nizam's Institute of Medical Sciences, Panjagutta, Hyderabad, Telangana, India
,
Gottumukkala Suryanarayana Raju
Department of Surgical Oncology, Nizam's Institute of Medical Sciences, Panjagutta, Hyderabad, Telangana, India
,
Priscilla Chandran
Department of Biochemistry, Nizam's Institute of Medical Sciences, Panjagutta, Hyderabad, Telangana, India
,
Maddali Lakshmi Srinivas
Department of Medical Oncology, Nizam's Institute of Medical Sciences, Panjagutta, Hyderabad, Telangana, India
› Author Affiliations Financial support and sponsorship Nil.
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Abstract

Introduction: Obesity has been associated with the development of breast cancer. The objectives were to study the association of serum adiponectin, serum leptin, and adiponectin–leptin ratio (ALR) in patients with breast cancer and matched controls, and to study their relationship with the various clinicopathological characteristics of breast cancer. Materials and Methods: A prospective, hospital-based case–control study was conducted on 40 patients with a first-confirmed histopathology diagnosis of breast cancer and 40 controls comprising individuals without a history of cancer simultaneously recruited from the health examination clinics during the same study period. Serum adiponectin and leptin concentrations were measured in a single run using commercially available kits (Human ADP/Acrp30 [adiponectin] enzyme-linked immune-sorbent assay [ELISA] kit and Human Leptin ELISA kit, Elabscience Biotechnology Co., Ltd) according to the manufacturer's instructions. Results:: Serum adiponectin levels were reduced significantly in breast cancer patients, in comparison to controls (P = 0.04), while serum leptin levels were increased significantly in breast cancer patients, in comparison to controls (P = 0.03). ALR was significantly lower in breast cancer cases, in comparison to controls (P = 0.05). There was no correlation between receptor status (estrogen receptor, progesterone receptor, Her2/neu), aggressiveness of disease in terms of tumor size, nodal metastases, stage, tumor grade, and serum adiponectin levels, leptin levels, or ALR. Body mass index was negatively correlated with serum adiponectin levels and ALR (r = 0.33, P = 0.03; r = 0.39, P = 0.01, respectively) and positively correlated with serum leptin levels (r = 0.34, P = 0.02). Conclusion: In summary, our results suggest that low serum adiponectin levels, ALR, and high serum leptin levels are associated with breast cancer.

Keywords

Adiponectin - adiponectin–leptin ratio - breast cancer - leptin


Publication History

Article published online:
17 June 2021

© 2018. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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