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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2019; 40(04): 510-514
DOI: 10.4103/ijmpo.ijmpo_199_18
Original Article

Thyroid Transcription Factor-1 Expression in Adenocarcinoma Lung and Its Association with Histomorphological Features

Saumya Shukla
Department of Pathology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
,
Nuzhat Husain
Department of Pathology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
,
Nidhi Anand
Department of Pathology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
,
Surya Kant
Department of Respiratory Medicine, King George’s Medical University, Lucknow, Uttar Pradesh, India
,
Rajiv Garg
Department of Respiratory Medicine, King George’s Medical University, Lucknow, Uttar Pradesh, India
,
SK Verma
Department of Respiratory Medicine, King George’s Medical University, Lucknow, Uttar Pradesh, India
,
Santosh Kumar
Department of Respiratory Medicine, King George’s Medical University, Lucknow, Uttar Pradesh, India
,
Ved Prakash
Department of Respiratory Medicine, King George’s Medical University, Lucknow, Uttar Pradesh, India
› Author Affiliations Financial support and sponsorship Nil.
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Abstract

Objectives: Thyroid transcription factor-1 (TTF-1) expression is frequently associated with adenocarcinoma lung. This study was undertaken with the objectives to assess the expression of TTF-1 in non-small cell lung carcinoma (NSCLC) with adenocarcinoma phenotype and to evaluate the TTF-1 expression with clinicopathological and histomorphological features. Materials and Methods: This was a tertiary care hospital-based case series that included 250 cases of NSCLC. TTF-1 immunostaining along with a basic panel of immunohistochemistry markers was performed. The histomorphological analysis was done to compare the morphological features of TTF-1-positive versus TTF-1-negative cases. Results: TTF-1 was positive in 144 cases (57.6%), while 106 cases were negative for TTF-1. The M: F ratio in the TTF-1-positive group was 1:2, and the mean age of the cases that expressed TTF-1 was 48.5 years. The most common pattern in the TTF-1-positive group was loose clusters or singly dispersed cells (77.78%), followed by the acinar (54.86%) and solid pattern (42.36%). In the TTF-1-negative group, 86.79% of cases had singly dispersed cells or loose cohesive clusters, followed by a solid pattern in 50.94% cases. Conclusion: TTF-1 is a useful and reliable marker for pulmonary adenocarcinoma. TTF-1 expression does not have any association with the patterns and degree of differentiation evident in the tumor.

Keywords

Adenocarcinoma - lung - morphological patterns - thyroid transcription factor-1 - tumor differentiation


Publication History

Received: 11 September 2018

Accepted: 04 August 2019

Article published online:
03 June 2021

© 2020. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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