CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2020; 41(04): 612-614
DOI: 10.4103/ijmpo.ijmpo_197_19
Practitioner Section

An Unusual Case of Acute Myeloid Leukemia with t(8:21) Presenting with Hypereosinophilia Showing Dysplastic Features

Pragya Singh
Department of Pathology, VMMC and Safdarjung Hospital, New Delhi, India
,
Meetu Aggrawal
Department of Pathology, VMMC and Safdarjung Hospital, New Delhi, India
,
Leelawathi Dawson
Department of Pathology, VMMC and Safdarjung Hospital, New Delhi, India
,
Amitabh Singh
Department of Pediatrics, VMMC and Safdarjung Hospital, New Delhi, India
› Author Affiliations
Financial support and sponsorship Nil.

Abstract

Acute myeloid leukemia (AML) with specific genetic abnormalities is a clinically, biologically, and prognostically distinct category with some of the entities in it displaying characteristic morphology. AML with t(8:21) is one such subtype carrying favorable prognosis with specific blast morphology. Eosinophilia, characteristically, has been described till date in AML with inv (16); however, hypereosinophilia with prominent dysplastic features has yet not been seen with any AML subtype. We report the case of an 8-year-old child presenting with massive splenomegaly, hypereosinophilia, and low marrow blast percentage. The initial clinical and hematological impression was that of a chronic myeloproliferative neoplasm, which was later diagnosed as AML with t(8:21) with the help of cytogenetic studies. The case report highlights the unusual and extremely rare presentation of this AML subtype and the importance of cytogenetic studies in definite categorization, especially in cases with overlapping morphological and immunophenotypic findings.



Publication History

Received: 14 September 2019

Accepted: 20 October 2019

Article published online:
17 May 2021

© 2020. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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