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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2020; 41(06): 832-840
DOI: 10.4103/ijmpo.ijmpo_188_20
Original Article

Does Neoadjuvant Chemotherapy Increase the Survival in Patients with Locally Advanced Gastric Cancer Patients? – A Real‑World Evidence

Murugesan Janarthinakani
Department of Medical Oncology, Madras Cancer Care Foundation, Chennai, Tamil Nadu, India
,
Selvaraj Kalaiselvi
Department of Community Medicine, AIIMS, Nagpur, Maharashtra, India
,
Rajamani Priyadarshini
Department of Research, Fenivi Research Solutions Private Limited, Chennai, Tamil Nadu, India
,
Seshachalam Arun
Department of Medical Oncology, GVN Cancer Institute, Trichy, Tamil Nadu, India
,
K Shashidhar
Vydehi Institute of Medical Sciences and Research Centre, Bengaluru, Karnataka, India
,
R Krishnakumar
Meenakshi Mission Hospital and Research Centre, Madurai, Tamil Nadu, India
,
N Manjunath
Vydehi Institute of Medical Sciences and Research Centre, Bengaluru, Karnataka, India
,
Sirigeri Roopa
Department of Oncology, Columbia Asia, Bengaluru, Karnataka, India
,
SG Raman
Department of Medical Oncology, Madras Cancer Care Foundation, Chennai, Tamil Nadu, India
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Financial support and sponsorship Nil.
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Abstract

Background: In locally advanced gastric cancer (LAGC), perioperative chemotherapy has shown to improve the survival to a larger extent compared to surgery alone. In India, the treatment followed for gastric carcinoma widely varies based on the type of health-care provider and treatment access. There is a paucity of data on the role of neoadjuvant chemotherapy on survival among LAGC patients in the Indian context. Aim: The aim of this study was to compare the disease-free survival (DFS) and overall survival (OS) between neoadjuvant and adjuvant chemotherapies among LAGC patients. Subjects and Methods: This was a retrospective cohort study involving clinical record review of LAGC patients enrolled between 2015 and 2017 from four tertiary cancer centers in South India. The date for the following events, namely diagnosis, recurrence, death, and last day of visit, was extracted in a mobile-based open-access tool. The median duration of OS and DFS between the neoadjuvant and adjuvant groups was compared using Kaplan–Meier survival curves. Results: Of the 137 patients, 70 (51%) had received neoadjuvant chemotherapy followed by surgery and 67 (49%) had adjuvant chemotherapy following the surgery. The mean (standard deviation) age of participants was 55.4 (11.4) years. Seventy-eight percent of the patients were diagnosed at Stage 3 or 4. Regional lymph nodes were involved in 83.9%. The median duration of follow-up was 15 months. The OS in the neoadjuvant and adjuvant groups was 18.6 months and 8.3 months, respectively. Nonregional lymph node involvement and adjacent organ involvement had independently increased the risk of death. Conclusion: Among LAGC patients, the neoadjuvant chemotherapy indicated a better median and DFS compared to the adjuvant group. However, these findings were statistically not significant. The current study has contributed an important finding to the existing evidences of clinical practice in an Indian setting. Further large-scale studies are required to validate the promising trend of using neoadjuvant chemotherapy in LAGC.

Keywords

Collaborative Medical Oncology Group - D2 lymphadenectomy - gastric carcinoma - stomach neoplasm - Structured Operational Research and Training Initiative


Publication History

Received: 24 April 2020

Accepted: 23 October 2020

Article published online:
14 May 2021

© 2020. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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